This file contains the enrichments of the genes selected as more relevant for the differentiation between the medulloblastoma subgroups: G3, G4, WNT and SHH. We also include here a new subgroup called Transition-G3-G4 that is the new subgroup proposed that exists between Group3 and Group4.
The enrichments are shown both with a table and a interactive plot. In addition, the enrichments are computed using all the genes of each subgroup and using the genes that are up or down expressed specifically in each subgroup, for better differentiation.
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00000 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 35 | 13 |
| 0.00002 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 164 | 17 |
| 0.00262 | GO:0007416 | synapse assembly | 117 | 12 |
| 0.00579 | GO:0007155 | cell adhesion | 1050 | 41 |
| 0.00579 | GO:0022610 | biological adhesion | 1056 | 41 |
| 0.01174 | GO:0034329 | cell junction assembly | 333 | 19 |
| 0.01533 | GO:0007268 | chemical synaptic transmission | 473 | 23 |
| 0.01533 | GO:0098916 | anterograde trans-synaptic signaling | 473 | 23 |
| 0.01604 | GO:0099537 | trans-synaptic signaling | 478 | 23 |
| 0.02183 | GO:0014912 | negative regulation of smooth muscle cell migration | 23 | 5 |
| 0.02183 | GO:0099536 | synaptic signaling | 497 | 23 |
| 0.02183 | GO:0098609 | cell-cell adhesion | 634 | 27 |
| 0.02357 | GO:0032501 | multicellular organismal process | 5090 | 127 |
| 0.02852 | GO:0030336 | negative regulation of cell migration | 256 | 15 |
| 0.03310 | GO:0040013 | negative regulation of locomotion | 291 | 16 |
| 0.03394 | GO:0120163 | negative regulation of cold-induced thermogenesis | 43 | 6 |
| 0.03736 | GO:2000146 | negative regulation of cell motility | 267 | 15 |
| 0.04116 | GO:0051271 | negative regulation of cellular component movement | 273 | 15 |
| 0.04116 | GO:0048856 | anatomical structure development | 3824 | 99 |
| 0.04116 | GO:0051241 | negative regulation of multicellular organismal process | 791 | 30 |
| 0.04729 | GO:0050808 | synapse organization | 248 | 14 |
| 0.04928 | GO:0050922 | negative regulation of chemotaxis | 49 | 6 |
| 0.04928 | GO:0014909 | smooth muscle cell migration | 49 | 6 |
| 0.03370 | GO:0071944 | cell periphery | 4545 | 116 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.03414 | GO:0008009 | chemokine activity | 42 | 7 |
| 0.03414 | GO:0003700 | DNA-binding transcription factor activity | 1231 | 51 |
| 0.03414 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 1193 | 50 |
| 0.03414 | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 1206 | 50 |
| 0.03522 | GO:0001067 | transcription regulatory region nucleic acid binding | 1293 | 52 |
| 0.03522 | GO:0000976 | transcription cis-regulatory region binding | 1292 | 52 |
| 0.03676 | GO:0042379 | chemokine receptor binding | 54 | 7 |
| 0.04106 | GO:0060089 | molecular transducer activity | 1086 | 44 |
| 0.04106 | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | 143 | 11 |
| 0.04106 | GO:0150100 | RNA binding involved in posttranscriptional gene silencing | 143 | 11 |
| 0.04106 | GO:1990837 | sequence-specific double-stranded DNA binding | 1351 | 53 |
| 0.04106 | GO:0038023 | signaling receptor activity | 1086 | 44 |
| 0.04106 | GO:0004917 | interleukin-7 receptor activity | 2 | 2 |
| 0.04106 | GO:0003690 | double-stranded DNA binding | 1413 | 54 |
| 0.04106 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 1031 | 42 |
| 0.04106 | GO:0038102 | activin receptor antagonist activity | 2 | 2 |
| 0.00515 | REAC:R-HSA-500792 | GPCR ligand binding | 419 | 26 |
| 0.00515 | REAC:R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 296 | 21 |
| 0.00717 | REAC:R-HSA-418594 | G alpha (i) signalling events | 368 | 23 |
| 0.00717 | REAC:R-HSA-388396 | GPCR downstream signalling | 978 | 45 |
| 0.00979 | REAC:R-HSA-372790 | Signaling by GPCR | 1038 | 46 |
| 0.03398 | REAC:R-HSA-380108 | Chemokine receptors bind chemokines | 53 | 7 |
| 0.00289 | TF:M01010_1 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 | 2423 | 95 |
| 0.00289 | TF:M01010 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN | 6335 | 201 |
| 0.00289 | TF:M04073 | Factor: POU2F2; motif: NWTRMATATKCAWN | 3151 | 117 |
| 0.00289 | TF:M10088 | Factor: TBP; motif: MTATAAAARS | 3740 | 134 |
| 0.00473 | TF:M01654_1 | Factor: DRI1; motif: AATTAA; match class: 1 | 4449 | 150 |
| 0.00473 | TF:M03546_1 | Factor: Dlx-5; motif: AATTAN; match class: 1 | 4449 | 150 |
| 0.00482 | TF:M02097_1 | Factor: LHX3; motif: ATTAAW; match class: 1 | 5026 | 165 |
| 0.00532 | TF:M04360_1 | Factor: HOXD11; motif: NNYMATAAAA; match class: 1 | 796 | 41 |
| 0.00669 | TF:M01124_1 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 | 1377 | 60 |
| 0.00866 | TF:M00252 | Factor: TATA; motif: STATAAAWRNNNNNN | 3546 | 123 |
| 0.00866 | TF:M01884_1 | Factor: IRF-7; motif: AAGWGAA; match class: 1 | 3517 | 122 |
| 0.00866 | TF:M12193 | Factor: GATA-3; motif: AGATAAGATCT | 4849 | 158 |
| 0.00990 | TF:M04073_1 | Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 | 1865 | 74 |
| 0.01055 | TF:M02087_1 | Factor: CDX-2; motif: TTTATN; match class: 1 | 3834 | 130 |
| 0.01421 | TF:M01723_1 | Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 | 385 | 24 |
| 0.01689 | TF:M01694 | Factor: YY2; motif: CCATTWN | 1909 | 74 |
| 0.01689 | TF:M02087 | Factor: CDX-2; motif: TTTATN | 7660 | 227 |
| 0.01693 | TF:M02079_1 | Factor: Isl2; motif: CTAATKR; match class: 1 | 897 | 42 |
| 0.01693 | TF:M04557_1 | Factor: SRY; motif: TCAATAMCATTGA; match class: 1 | 3784 | 127 |
| 0.01792 | TF:M04557 | Factor: SRY; motif: TCAATAMCATTGA | 7715 | 227 |
| 0.01792 | TF:M08836_1 | Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 | 619 | 32 |
| 0.01792 | TF:M00351 | Factor: GATA-3; motif: ANAGATMWWA | 2046 | 77 |
| 0.01792 | TF:M02112_1 | Factor: OC-2; motif: TCAATA; match class: 1 | 1832 | 71 |
| 0.01792 | TF:M08836 | Factor: OCT-2; motif: ATGMATATGCWAAT | 2812 | 99 |
| 0.01792 | TF:M01124 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN | 4669 | 150 |
| 0.01792 | TF:M07278 | Factor: Dlx-3; motif: NTAATTNVN | 2716 | 97 |
| 0.01792 | TF:M08520_1 | Factor: CDP:SRF; motif: NCCWTAYAAGGTMNKRATCRATN; match class: 1 | 2461 | 89 |
| 0.01792 | TF:M00133_1 | Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 | 1008 | 45 |
| 0.01792 | TF:M03581 | Factor: TBP; motif: NGNNTATAAAA | 5412 | 169 |
| 0.01792 | TF:M11894 | Factor: Oct-2; motif: NNNATTATGCAW | 2844 | 100 |
| 0.01891 | TF:M11585_1 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 | 1044 | 46 |
| 0.02116 | TF:M00136 | Factor: Oct-1; motif: NNGAATATKCANNNN | 3225 | 110 |
| 0.02116 | TF:M02112 | Factor: OC-2; motif: TCAATA | 5787 | 178 |
| 0.02131 | TF:M01255 | Factor: ipf1; motif: RNWCATTAANWN | 3048 | 105 |
| 0.02315 | TF:M00026 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN | 815 | 38 |
| 0.02324 | TF:M00407 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN | 1060 | 46 |
| 0.02366 | TF:M04556 | Factor: SRY; motif: AACAATNNNCATTGTT | 6044 | 184 |
| 0.02650 | TF:M07270_1 | Factor: TEF-3; motif: GNTATTTTT; match class: 1 | 3445 | 115 |
| 0.02650 | TF:M02909_1 | Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 | 707 | 34 |
| 0.02650 | TF:M08775_1 | Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 | 2165 | 79 |
| 0.02650 | TF:M00805_1 | Factor: TCF-7; motif: TCAAAG; match class: 1 | 4222 | 136 |
| 0.02650 | TF:M03858_1 | Factor: TCF-3; motif: CTTTGA; match class: 1 | 4222 | 136 |
| 0.02650 | TF:M11908_1 | Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 | 979 | 43 |
| 0.02747 | TF:M01149 | Factor: DMRT4; motif: AATGTADCAAWTT | 1398 | 56 |
| 0.02747 | TF:M04635 | Factor: TEF-5; motif: AAAAATAT | 2449 | 87 |
| 0.02747 | TF:M00102 | Factor: CDP; motif: NWNATCGATTANYNN | 3127 | 106 |
| 0.02974 | TF:M00148_1 | Factor: SRY; motif: AAACWAM; match class: 1 | 3353 | 112 |
| 0.03183 | TF:M04556_1 | Factor: SRY; motif: AACAATNNNCATTGTT; match class: 1 | 4704 | 148 |
| 0.03409 | TF:M07230 | Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG | 2861 | 98 |
| 0.03487 | TF:M07298_1 | Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 | 189 | 14 |
| 0.03497 | TF:M03559 | Factor: Pit-1; motif: NNWWATTCAT | 4039 | 130 |
| 0.03540 | TF:M07476_1 | Factor: Lhx8; motif: TGATTG; match class: 1 | 2337 | 83 |
| 0.03551 | TF:M10797 | Factor: HOXA10; motif: RGTCGTAAAAN | 4269 | 136 |
| 0.03856 | TF:M10801 | Factor: HOXA10; motif: NRTCGTAAANN | 2987 | 101 |
| 0.03856 | TF:M00802_1 | Factor: Pit-1; motif: NMTTCATAAWTATWNMNA; match class: 1 | 855 | 38 |
| 0.03952 | TF:M03997_1 | Factor: GATA3; motif: NGATAANN; match class: 1 | 505 | 26 |
| 0.03952 | TF:M08918_1 | Factor: GATA-3; motif: WGATAASN; match class: 1 | 505 | 26 |
| 0.03952 | TF:M11899 | Factor: Oct-2; motif: NTGCATATGCAN | 4247 | 135 |
| 0.04050 | TF:M03549_1 | Factor: GATA-4; motif: AGATAAN; match class: 1 | 739 | 34 |
| 0.04276 | TF:M03548_1 | Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 | 772 | 35 |
| 0.04328 | TF:M11571 | Factor: HNF-3alpha; motif: YTRWGTMAATATTTRCWYWN | 3298 | 109 |
| 0.04328 | TF:M07457_1 | Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 | 1277 | 51 |
| 0.04425 | TF:M05611 | Factor: SALL3; motif: CGAGTCTGAAK | 15 | 4 |
| 0.04425 | TF:M11736 | Factor: TLX; motif: NNAAGTCAN | 1378 | 54 |
| 0.04587 | TF:M11899_1 | Factor: Oct-2; motif: NTGCATATGCAN; match class: 1 | 3418 | 112 |
| 0.04587 | TF:M04609 | Factor: AP-3; motif: TKGAAAKN | 3345 | 110 |
| 0.04599 | TF:M08765_1 | Factor: GATA-1; motif: NGATAAN; match class: 1 | 300 | 18 |
| 0.04599 | TF:M07214_1 | Factor: GATA3; motif: AGATAAGA; match class: 1 | 300 | 18 |
| 0.04599 | TF:M03216_1 | Factor: GATA-6; motif: AGATAAN; match class: 1 | 300 | 18 |
| 0.04599 | TF:M00789_1 | Factor: GATA; motif: WGATARN; match class: 1 | 300 | 18 |
| 0.04599 | TF:M01292_1 | Factor: HOXA13; motif: ATAAMA; match class: 1 | 6372 | 189 |
| 0.04599 | TF:M11286 | Factor: Fra-1; motif: NATGAWTCAYN | 2416 | 84 |
| 0.04599 | TF:M01230_1 | Factor: ZNF333; motif: ATAAT; match class: 1 | 8866 | 250 |
| 0.04725 | TF:M01878_1 | Factor: GATA-3; motif: AGATAA; match class: 1 | 3211 | 106 |
| 0.04923 | TF:M10535_1 | Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 | 1969 | 71 |
| 0.04956 | TF:M11929_1 | Factor: POU3F1; motif: NTAATKWATGCNN; match class: 1 | 1395 | 54 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00000 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 35 | 12 |
| 0.00000 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 164 | 14 |
| 0.00008 | GO:0034329 | cell junction assembly | 333 | 16 |
| 0.00010 | GO:0007416 | synapse assembly | 117 | 10 |
| 0.00074 | GO:0007155 | cell adhesion | 1050 | 27 |
| 0.00074 | GO:0022610 | biological adhesion | 1056 | 27 |
| 0.00075 | GO:0098609 | cell-cell adhesion | 634 | 20 |
| 0.00510 | GO:0034330 | cell junction organization | 492 | 16 |
| 0.03344 | GO:0050808 | synapse organization | 248 | 10 |
| 0.03474 | GO:0007268 | chemical synaptic transmission | 473 | 14 |
| 0.03474 | GO:0098916 | anterograde trans-synaptic signaling | 473 | 14 |
| 0.03551 | GO:0099537 | trans-synaptic signaling | 478 | 14 |
| 0.04041 | GO:0018916 | nitrobenzene metabolic process | 3 | 2 |
| 0.04041 | GO:0051410 | detoxification of nitrogen compound | 3 | 2 |
| 0.04041 | GO:0070458 | cellular detoxification of nitrogen compound | 3 | 2 |
| 0.04041 | GO:0099536 | synaptic signaling | 497 | 14 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.03395 | GO:0072359 | circulatory system development | 745 | 49 |
| 0.03788 | GO:0051241 | negative regulation of multicellular organismal process | 791 | 49 |
| 0.03788 | GO:1902869 | regulation of amacrine cell differentiation | 3 | 3 |
| 0.03788 | GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration | 3 | 3 |
| 0.03788 | GO:0032501 | multicellular organismal process | 5090 | 217 |
| 0.04034 | GO:0051093 | negative regulation of developmental process | 587 | 39 |
| 0.00188 | GO:0031226 | intrinsic component of plasma membrane | 1419 | 80 |
| 0.00194 | GO:0005887 | integral component of plasma membrane | 1353 | 76 |
| 0.02207 | GO:0071944 | cell periphery | 4545 | 193 |
| 0.03809 | GO:0001067 | transcription regulatory region nucleic acid binding | 1293 | 65 |
| 0.03809 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 1031 | 55 |
| 0.03809 | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 1206 | 63 |
| 0.03809 | GO:0003700 | DNA-binding transcription factor activity | 1231 | 65 |
| 0.03809 | GO:0000976 | transcription cis-regulatory region binding | 1292 | 65 |
| 0.03809 | GO:0015318 | inorganic molecular entity transmembrane transporter activity | 577 | 36 |
| 0.03809 | GO:0022834 | ligand-gated channel activity | 118 | 12 |
| 0.03809 | GO:0022836 | gated channel activity | 251 | 20 |
| 0.03809 | GO:0022848 | acetylcholine-gated cation-selective channel activity | 13 | 4 |
| 0.03809 | GO:0022857 | transmembrane transporter activity | 836 | 46 |
| 0.03809 | GO:0022890 | inorganic cation transmembrane transporter activity | 474 | 32 |
| 0.03809 | GO:0008324 | cation transmembrane transporter activity | 517 | 33 |
| 0.03809 | GO:0008009 | chemokine activity | 42 | 7 |
| 0.03809 | GO:0005261 | cation channel activity | 270 | 21 |
| 0.03809 | GO:0005216 | ion channel activity | 347 | 24 |
| 0.03809 | GO:0046873 | metal ion transmembrane transporter activity | 359 | 25 |
| 0.03809 | GO:0015276 | ligand-gated ion channel activity | 118 | 12 |
| 0.03809 | GO:0099094 | ligand-gated cation channel activity | 97 | 11 |
| 0.03809 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 1193 | 64 |
| 0.03809 | GO:0000987 | cis-regulatory region sequence-specific DNA binding | 1045 | 55 |
| 0.03809 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity | 10 | 4 |
| 0.03824 | GO:0015075 | ion transmembrane transporter activity | 677 | 39 |
| 0.04234 | GO:0038102 | activin receptor antagonist activity | 2 | 2 |
| 0.04234 | GO:0150100 | RNA binding involved in posttranscriptional gene silencing | 143 | 13 |
| 0.04234 | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | 143 | 13 |
| 0.04234 | GO:0004917 | interleukin-7 receptor activity | 2 | 2 |
| 0.04543 | GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 25 | 5 |
| 0.04543 | GO:0005215 | transporter activity | 927 | 49 |
| 0.04954 | GO:0022803 | passive transmembrane transporter activity | 387 | 25 |
| 0.04954 | GO:1990837 | sequence-specific double-stranded DNA binding | 1351 | 66 |
| 0.04954 | GO:0015267 | channel activity | 387 | 25 |
| 0.00431 | MIRNA:hsa-miR-335-5p | hsa-miR-335-5p | 2166 | 112 |
| 0.00084 | TF:M10088 | Factor: TBP; motif: MTATAAAARS | 3740 | 178 |
| 0.00084 | TF:M01010_1 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 | 2423 | 127 |
| 0.00196 | TF:M02087_1 | Factor: CDX-2; motif: TTTATN; match class: 1 | 3834 | 179 |
| 0.00943 | TF:M01654_1 | Factor: DRI1; motif: AATTAA; match class: 1 | 4449 | 197 |
| 0.00943 | TF:M03546_1 | Factor: Dlx-5; motif: AATTAN; match class: 1 | 4449 | 197 |
| 0.00943 | TF:M12193 | Factor: GATA-3; motif: AGATAAGATCT | 4849 | 211 |
| 0.00943 | TF:M04073 | Factor: POU2F2; motif: NWTRMATATKCAWN | 3151 | 148 |
| 0.01044 | TF:M07204_1 | Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 | 740 | 48 |
| 0.01044 | TF:M01010 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN | 6335 | 263 |
| 0.01088 | TF:M02087 | Factor: CDX-2; motif: TTTATN | 7660 | 308 |
| 0.01263 | TF:M04360_1 | Factor: HOXD11; motif: NNYMATAAAA; match class: 1 | 796 | 50 |
| 0.01263 | TF:M00252 | Factor: TATA; motif: STATAAAWRNNNNNN | 3546 | 161 |
| 0.01593 | TF:M04557 | Factor: SRY; motif: TCAATAMCATTGA | 7715 | 308 |
| 0.01593 | TF:M01884_1 | Factor: IRF-7; motif: AAGWGAA; match class: 1 | 3517 | 159 |
| 0.01682 | TF:M02097_1 | Factor: LHX3; motif: ATTAAW; match class: 1 | 5026 | 214 |
| 0.01740 | TF:M02112_1 | Factor: OC-2; motif: TCAATA; match class: 1 | 1832 | 93 |
| 0.01740 | TF:M01694 | Factor: YY2; motif: CCATTWN | 1909 | 96 |
| 0.01740 | TF:M04555_1 | Factor: SRY; motif: AACAATANCATTGTT; match class: 1 | 2638 | 125 |
| 0.01974 | TF:M02112 | Factor: OC-2; motif: TCAATA | 5787 | 240 |
| 0.02381 | TF:M10853 | Factor: Cdx-1; motif: NGCMATAAAAC | 1154 | 64 |
| 0.02671 | TF:M11585_1 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 | 1044 | 59 |
| 0.02729 | TF:M01124_1 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 | 1377 | 73 |
| 0.03059 | TF:M03581 | Factor: TBP; motif: NGNNTATAAAA | 5412 | 225 |
| 0.03082 | TF:M04235 | Factor: FOXC2; motif: NGTMAATATTKACN | 359 | 27 |
| 0.03290 | TF:M07270_1 | Factor: TEF-3; motif: GNTATTTTT; match class: 1 | 3445 | 153 |
| 0.03290 | TF:M00407 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN | 1060 | 59 |
| 0.03480 | TF:M03559_1 | Factor: Pit-1; motif: NNWWATTCAT; match class: 1 | 1042 | 58 |
| 0.03480 | TF:M01878_1 | Factor: GATA-3; motif: AGATAA; match class: 1 | 3211 | 144 |
| 0.04702 | TF:M12041_1 | Factor: TEF-1; motif: CRCATWCCN; match class: 1 | 519 | 34 |
| 0.04702 | TF:M04073_1 | Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 | 1865 | 91 |
| 0.04702 | TF:M03581_1 | Factor: TBP; motif: NGNNTATAAAA; match class: 1 | 1517 | 77 |
| 0.04702 | TF:M00026 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN | 815 | 47 |
| 0.04702 | TF:M00102 | Factor: CDP; motif: NWNATCGATTANYNN | 3127 | 139 |
| 0.04702 | TF:M07214_1 | Factor: GATA3; motif: AGATAAGA; match class: 1 | 300 | 23 |
| 0.04702 | TF:M10535_1 | Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 | 1969 | 95 |
| 0.04702 | TF:M00789_1 | Factor: GATA; motif: WGATARN; match class: 1 | 300 | 23 |
| 0.04702 | TF:M07205 | Factor: CEBPA; motif: ATTGCAYAAYN | 1965 | 95 |
| 0.04702 | TF:M03216_1 | Factor: GATA-6; motif: AGATAAN; match class: 1 | 300 | 23 |
| 0.04702 | TF:M08918_1 | Factor: GATA-3; motif: WGATAASN; match class: 1 | 505 | 33 |
| 0.04702 | TF:M11585 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN | 4231 | 180 |
| 0.04702 | TF:M03997_1 | Factor: GATA3; motif: NGATAANN; match class: 1 | 505 | 33 |
| 0.04702 | TF:M08765_1 | Factor: GATA-1; motif: NGATAAN; match class: 1 | 300 | 23 |
| 0.04981 | TF:M07364_1 | Factor: NF-1; motif: TTGGCNN; match class: 1 | 552 | 35 |
| 0.04981 | TF:M00148_1 | Factor: SRY; motif: AAACWAM; match class: 1 | 3353 | 147 |
| 0.04981 | TF:M02909_1 | Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 | 707 | 42 |
| 0.04981 | TF:M04557_1 | Factor: SRY; motif: TCAATAMCATTGA; match class: 1 | 3784 | 163 |
| 0.04992 | TF:M00133_1 | Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 | 1008 | 55 |
| 0.04992 | TF:M01292_1 | Factor: HOXA13; motif: ATAAMA; match class: 1 | 6372 | 255 |
| 0.04992 | TF:M01124 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN | 4669 | 195 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00000 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 35 | 13 |
| 0.00000 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 164 | 19 |
| 0.00106 | GO:0034329 | cell junction assembly | 333 | 23 |
| 0.00126 | GO:0007416 | synapse assembly | 117 | 13 |
| 0.00162 | GO:0034330 | cell junction organization | 492 | 28 |
| 0.00162 | GO:0032501 | multicellular organismal process | 5090 | 149 |
| 0.00347 | GO:0051241 | negative regulation of multicellular organismal process | 791 | 37 |
| 0.00500 | GO:0030336 | negative regulation of cell migration | 256 | 18 |
| 0.00708 | GO:0040013 | negative regulation of locomotion | 291 | 19 |
| 0.00708 | GO:2000146 | negative regulation of cell motility | 267 | 18 |
| 0.00816 | GO:0051271 | negative regulation of cellular component movement | 273 | 18 |
| 0.00816 | GO:0050808 | synapse organization | 248 | 17 |
| 0.00860 | GO:0007155 | cell adhesion | 1050 | 43 |
| 0.00913 | GO:0022610 | biological adhesion | 1056 | 43 |
| 0.00975 | GO:0060073 | micturition | 4 | 3 |
| 0.00975 | GO:0098609 | cell-cell adhesion | 634 | 30 |
| 0.01374 | GO:0072359 | circulatory system development | 745 | 33 |
| 0.01722 | GO:0007268 | chemical synaptic transmission | 473 | 24 |
| 0.01722 | GO:0098916 | anterograde trans-synaptic signaling | 473 | 24 |
| 0.01913 | GO:0032502 | developmental process | 4171 | 120 |
| 0.01913 | GO:0099537 | trans-synaptic signaling | 478 | 24 |
| 0.01922 | GO:0014912 | negative regulation of smooth muscle cell migration | 23 | 5 |
| 0.02424 | GO:0007275 | multicellular organism development | 3397 | 101 |
| 0.02495 | GO:0048856 | anatomical structure development | 3824 | 111 |
| 0.02780 | GO:0099536 | synaptic signaling | 497 | 24 |
| 0.04361 | GO:0120163 | negative regulation of cold-induced thermogenesis | 43 | 6 |
| 0.00198 | GO:0071944 | cell periphery | 4545 | 135 |
| 0.00770 | GO:0016342 | catenin complex | 32 | 6 |
| 0.00770 | GO:0031226 | intrinsic component of plasma membrane | 1419 | 53 |
| 0.01386 | GO:0005886 | plasma membrane | 4147 | 119 |
| 0.01493 | GO:0005887 | integral component of plasma membrane | 1353 | 49 |
| 0.02392 | GO:0048179 | activin receptor complex | 7 | 3 |
| 0.01051 | REAC:R-HSA-9031628 | NGF-stimulated transcription | 38 | 7 |
| 0.01510 | REAC:R-HSA-1433617 | Regulation of signaling by NODAL | 10 | 4 |
| 0.03597 | REAC:R-HSA-629587 | Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | 6 | 3 |
| 0.03597 | REAC:R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 55 | 7 |
| 0.03608 | REAC:R-HSA-166520 | Signaling by NTRKs | 119 | 10 |
| 0.03973 | REAC:R-HSA-187037 | Signaling by NTRK1 (TRKA) | 101 | 9 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.02914 | GO:1902869 | regulation of amacrine cell differentiation | 3 | 3 |
| 0.02914 | GO:0035881 | amacrine cell differentiation | 8 | 4 |
| 0.02384 | GO:0008009 | chemokine activity | 42 | 7 |
| 0.04176 | GO:0038102 | activin receptor antagonist activity | 2 | 2 |
| 0.04176 | GO:0000976 | transcription cis-regulatory region binding | 1292 | 47 |
| 0.04176 | GO:0003700 | DNA-binding transcription factor activity | 1231 | 46 |
| 0.04176 | GO:0001067 | transcription regulatory region nucleic acid binding | 1293 | 47 |
| 0.04176 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 1193 | 44 |
| 0.04176 | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 1206 | 45 |
| 0.04176 | GO:0004917 | interleukin-7 receptor activity | 2 | 2 |
| 0.04176 | GO:0042379 | chemokine receptor binding | 54 | 7 |
| 0.04738 | GO:1990837 | sequence-specific double-stranded DNA binding | 1351 | 48 |
| 0.03520 | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 89 | 9 |
| 0.01297 | REAC:R-HSA-500792 | GPCR ligand binding | 419 | 23 |
| 0.01297 | REAC:R-HSA-388396 | GPCR downstream signalling | 978 | 42 |
| 0.01297 | REAC:R-HSA-372790 | Signaling by GPCR | 1038 | 43 |
| 0.01745 | REAC:R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 296 | 18 |
| 0.02035 | REAC:R-HSA-380108 | Chemokine receptors bind chemokines | 53 | 7 |
| 0.02238 | REAC:R-HSA-418594 | G alpha (i) signalling events | 368 | 20 |
| 0.03188 | REAC:R-HSA-6783783 | Interleukin-10 signaling | 43 | 6 |
| 0.00000 | TF:M04073 | Factor: POU2F2; motif: NWTRMATATKCAWN | 3151 | 120 |
| 0.00002 | TF:M02097_1 | Factor: LHX3; motif: ATTAAW; match class: 1 | 5026 | 162 |
| 0.00002 | TF:M01230_1 | Factor: ZNF333; motif: ATAAT; match class: 1 | 8866 | 247 |
| 0.00004 | TF:M01124 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN | 4669 | 151 |
| 0.00005 | TF:M08836 | Factor: OCT-2; motif: ATGMATATGCWAAT | 2812 | 103 |
| 0.00005 | TF:M01124_1 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 | 1377 | 62 |
| 0.00005 | TF:M03546_1 | Factor: Dlx-5; motif: AATTAN; match class: 1 | 4449 | 144 |
| 0.00005 | TF:M01654_1 | Factor: DRI1; motif: AATTAA; match class: 1 | 4449 | 144 |
| 0.00005 | TF:M01010_1 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 | 2423 | 92 |
| 0.00005 | TF:M02087 | Factor: CDX-2; motif: TTTATN | 7660 | 218 |
| 0.00006 | TF:M12193 | Factor: GATA-3; motif: AGATAAGATCT | 4849 | 153 |
| 0.00006 | TF:M01010 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN | 6335 | 188 |
| 0.00006 | TF:M02087_1 | Factor: CDX-2; motif: TTTATN; match class: 1 | 3834 | 128 |
| 0.00006 | TF:M04556 | Factor: SRY; motif: AACAATNNNCATTGTT | 6044 | 181 |
| 0.00007 | TF:M04073_1 | Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 | 1865 | 75 |
| 0.00009 | TF:M02112 | Factor: OC-2; motif: TCAATA | 5787 | 174 |
| 0.00010 | TF:M11894 | Factor: Oct-2; motif: NNNATTATGCAW | 2844 | 101 |
| 0.00010 | TF:M04556_1 | Factor: SRY; motif: AACAATNNNCATTGTT; match class: 1 | 4704 | 148 |
| 0.00011 | TF:M10088 | Factor: TBP; motif: MTATAAAARS | 3740 | 124 |
| 0.00015 | TF:M03581 | Factor: TBP; motif: NGNNTATAAAA | 5412 | 164 |
| 0.00015 | TF:M04557 | Factor: SRY; motif: TCAATAMCATTGA | 7715 | 216 |
| 0.00020 | TF:M01884_1 | Factor: IRF-7; motif: AAGWGAA; match class: 1 | 3517 | 117 |
| 0.00020 | TF:M00102 | Factor: CDP; motif: NWNATCGATTANYNN | 3127 | 107 |
| 0.00021 | TF:M07270_1 | Factor: TEF-3; motif: GNTATTTTT; match class: 1 | 3445 | 115 |
| 0.00026 | TF:M00252 | Factor: TATA; motif: STATAAAWRNNNNNN | 3546 | 117 |
| 0.00026 | TF:M04557_1 | Factor: SRY; motif: TCAATAMCATTGA; match class: 1 | 3784 | 123 |
| 0.00026 | TF:M04360_1 | Factor: HOXD11; motif: NNYMATAAAA; match class: 1 | 796 | 40 |
| 0.00033 | TF:M02112_1 | Factor: OC-2; motif: TCAATA; match class: 1 | 1832 | 71 |
| 0.00035 | TF:M10801 | Factor: HOXA10; motif: NRTCGTAAANN | 2987 | 102 |
| 0.00035 | TF:M01694 | Factor: YY2; motif: CCATTWN | 1909 | 73 |
| 0.00036 | TF:M08520_1 | Factor: CDP:SRF; motif: NCCWTAYAAGGTMNKRATCRATN; match class: 1 | 2461 | 88 |
| 0.00036 | TF:M08201 | Factor: CDP:HOXA13; motif: ATCGATYAYSYCRTAAA | 6121 | 178 |
| 0.00037 | TF:M10797 | Factor: HOXA10; motif: RGTCGTAAAAN | 4269 | 134 |
| 0.00037 | TF:M00346 | Factor: GATA-1; motif: NCWGATAACA | 3388 | 112 |
| 0.00043 | TF:M00133_1 | Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 | 1008 | 46 |
| 0.00044 | TF:M04555 | Factor: SRY; motif: AACAATANCATTGTT | 5414 | 161 |
| 0.00050 | TF:M07270 | Factor: TEF-3; motif: GNTATTTTT | 7818 | 215 |
| 0.00052 | TF:M03813_1 | Factor: BRN1; motif: HAATGCN; match class: 1 | 5433 | 161 |
| 0.00056 | TF:M09646 | Factor: Oct3; motif: NYWTTSWTATGCAAAT | 4352 | 135 |
| 0.00060 | TF:M00148_1 | Factor: SRY; motif: AAACWAM; match class: 1 | 3353 | 110 |
| 0.00068 | TF:M01292_1 | Factor: HOXA13; motif: ATAAMA; match class: 1 | 6372 | 182 |
| 0.00072 | TF:M07205 | Factor: CEBPA; motif: ATTGCAYAAYN | 1965 | 73 |
| 0.00075 | TF:M10535_1 | Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 | 1969 | 73 |
| 0.00076 | TF:M00805_1 | Factor: TCF-7; motif: TCAAAG; match class: 1 | 4222 | 131 |
| 0.00076 | TF:M03858_1 | Factor: TCF-3; motif: CTTTGA; match class: 1 | 4222 | 131 |
| 0.00112 | TF:M01878_1 | Factor: GATA-3; motif: AGATAA; match class: 1 | 3211 | 105 |
| 0.00112 | TF:M00802 | Factor: Pit-1; motif: NMTTCATAAWTATWNMNA | 3649 | 116 |
| 0.00112 | TF:M00423 | Factor: FOXJ2; motif: AYMATAATATTTKN | 5302 | 156 |
| 0.00131 | TF:M00136 | Factor: Oct-1; motif: NNGAATATKCANNNN | 3225 | 105 |
| 0.00132 | TF:M04609 | Factor: AP-3; motif: TKGAAAKN | 3345 | 108 |
| 0.00133 | TF:M03564_1 | Factor: SATB1; motif: NTTTAT; match class: 1 | 9202 | 242 |
| 0.00140 | TF:M01654 | Factor: DRI1; motif: AATTAA | 8362 | 224 |
| 0.00140 | TF:M03546 | Factor: Dlx-5; motif: AATTAN | 8362 | 224 |
| 0.00142 | TF:M00026 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN | 815 | 38 |
| 0.00144 | TF:M11899 | Factor: Oct-2; motif: NTGCATATGCAN | 4247 | 130 |
| 0.00151 | TF:M11585_1 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 | 1044 | 45 |
| 0.00190 | TF:M04635 | Factor: TEF-5; motif: AAAAATAT | 2449 | 84 |
| 0.00193 | TF:M01723_1 | Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 | 385 | 23 |
| 0.00202 | TF:M01149 | Factor: DMRT4; motif: AATGTADCAAWTT | 1398 | 55 |
| 0.00207 | TF:M00407 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN | 1060 | 45 |
| 0.00260 | TF:M03849_1 | Factor: Sox-4; motif: AACAAA; match class: 1 | 6977 | 192 |
| 0.00260 | TF:M07230 | Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG | 2861 | 94 |
| 0.00260 | TF:M04335 | Factor: HMX3; motif: NNCAMTTAANN | 4183 | 127 |
| 0.00263 | TF:M09597 | Factor: C/EBPbeta; motif: NATTGCRYAAYN | 2326 | 80 |
| 0.00274 | TF:M03555_1 | Factor: NFATc2; motif: GGAAAA; match class: 1 | 8590 | 227 |
| 0.00274 | TF:M01886_1 | Factor: NFATc3; motif: GGAAAA; match class: 1 | 8590 | 227 |
| 0.00274 | TF:M01281_1 | Factor: NFATc2; motif: GGAAAA; match class: 1 | 8590 | 227 |
| 0.00282 | TF:M00347 | Factor: GATA-1; motif: MNAGATAANR | 3465 | 109 |
| 0.00329 | TF:M00351 | Factor: GATA-3; motif: ANAGATMWWA | 2046 | 72 |
| 0.00329 | TF:M08792 | Factor: MEL1; motif: GATAAGATAA | 1789 | 65 |
| 0.00346 | TF:M01255 | Factor: ipf1; motif: RNWCATTAANWN | 3048 | 98 |
| 0.00346 | TF:M01292 | Factor: HOXA13; motif: ATAAMA | 10296 | 262 |
| 0.00351 | TF:M08775_1 | Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 | 2165 | 75 |
| 0.00369 | TF:M08201_1 | Factor: CDP:HOXA13; motif: ATCGATYAYSYCRTAAA; match class: 1 | 2396 | 81 |
| 0.00392 | TF:M02909_1 | Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 | 707 | 33 |
| 0.00446 | TF:M03559 | Factor: Pit-1; motif: NNWWATTCAT | 4039 | 122 |
| 0.00457 | TF:M07476_1 | Factor: Lhx8; motif: TGATTG; match class: 1 | 2337 | 79 |
| 0.00495 | TF:M04300 | Factor: Dlx-2; motif: NYAATTAN | 4215 | 126 |
| 0.00516 | TF:M08976_1 | Factor: SRY; motif: AACAATNR; match class: 1 | 6181 | 172 |
| 0.00549 | TF:M10799 | Factor: HOXA10; motif: NRTCGTAAANN | 4352 | 129 |
| 0.00549 | TF:M11929_1 | Factor: POU3F1; motif: NTAATKWATGCNN; match class: 1 | 1395 | 53 |
| 0.00564 | TF:M11585 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN | 4231 | 126 |
| 0.00574 | TF:M01451 | Factor: HOXB8; motif: NNNNGYAATTAATANW | 1121 | 45 |
| 0.00574 | TF:M11899_1 | Factor: Oct-2; motif: NTGCATATGCAN; match class: 1 | 3418 | 106 |
| 0.00633 | TF:M10092_1 | Factor: TEF-1; motif: RCATTCCWGNNN; match class: 1 | 237 | 16 |
| 0.00633 | TF:M07457 | Factor: Hoxa9; motif: NTTAAWTAMA | 3630 | 111 |
| 0.00638 | TF:M07278 | Factor: Dlx-3; motif: NTAATTNVN | 2716 | 88 |
| 0.00698 | TF:M02079_1 | Factor: Isl2; motif: CTAATKR; match class: 1 | 897 | 38 |
| 0.00698 | TF:M04075 | Factor: POU2F3; motif: ATGMATATKCAW | 1168 | 46 |
| 0.00733 | TF:M03950 | Factor: CDP; motif: ATCGATNNNNNATCRAT | 3243 | 101 |
| 0.00770 | TF:M08203_1 | Factor: CDP:T-bet; motif: NTCACACNYYRATCRATM; match class: 1 | 1140 | 45 |
| 0.00770 | TF:M03548_1 | Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 | 772 | 34 |
| 0.00844 | TF:M02026_1 | Factor: MEF-2D; motif: WAAATAR; match class: 1 | 1864 | 65 |
| 0.00844 | TF:M10701 | Factor: HOXB5; motif: GTCATTAN | 4572 | 133 |
| 0.00859 | TF:M08836_1 | Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 | 619 | 29 |
| 0.00896 | TF:M02006_1 | Factor: GATA-5; motif: TATCTN; match class: 1 | 2361 | 78 |
| 0.00912 | TF:M04068 | Factor: POU1F1; motif: NNNATGMATAWTTAATN | 2673 | 86 |
| 0.00942 | TF:M04442 | Factor: UNCX; motif: NTAATNNAATTAN | 1763 | 62 |
| 0.00942 | TF:M04555_1 | Factor: SRY; motif: AACAATANCATTGTT; match class: 1 | 2638 | 85 |
| 0.00950 | TF:M12070 | Factor: CIZ; motif: TTTTNNNNNNNNNNNNNAAAAA | 1988 | 68 |
| 0.00953 | TF:M01883_1 | Factor: IRF-4; motif: GAAARTA; match class: 1 | 2297 | 76 |
| 0.00953 | TF:M08918_1 | Factor: GATA-3; motif: WGATAASN; match class: 1 | 505 | 25 |
| 0.00953 | TF:M11507 | Factor: CDP; motif: NTATTGATYR | 2409 | 79 |
| 0.00953 | TF:M03997_1 | Factor: GATA3; motif: NGATAANN; match class: 1 | 505 | 25 |
| 0.00953 | TF:M01324 | Factor: BRN1; motif: NANNTATGCATAATNNA | 3848 | 115 |
| 0.00953 | TF:M12195 | Factor: GATA-3; motif: MGATAASATCT | 2956 | 93 |
| 0.00953 | TF:M08772 | Factor: HOXA6; motif: NYMATTAN | 6055 | 167 |
| 0.00953 | TF:M04235 | Factor: FOXC2; motif: NGTMAATATTKACN | 359 | 20 |
| 0.00953 | TF:M10724 | Factor: HOXD8; motif: GYMATTAN | 2257 | 75 |
| 0.00953 | TF:M01408 | Factor: Brn-3c; motif: NNTTATTAATKANKNC | 3768 | 113 |
| 0.00955 | TF:M01723 | Factor: SATB1; motif: AKWAWTAAHGRYMNWW | 2454 | 80 |
| 0.00955 | TF:M10031_1 | Factor: ipf1; motif: TGATTGATK; match class: 1 | 2766 | 88 |
| 0.00955 | TF:M12070_1 | Factor: CIZ; motif: TTTTNNNNNNNNNNNNNAAAAA; match class: 1 | 1959 | 67 |
| 0.00992 | TF:M02027_1 | Factor: PARP; motif: TTTCYN; match class: 1 | 9298 | 238 |
| 0.00992 | TF:M07213 | Factor: GATA2; motif: NNNTTCTTATCTSN | 2929 | 92 |
| 0.01058 | TF:M02025_1 | Factor: MEF-2C; motif: TATTTWT; match class: 1 | 5856 | 162 |
| 0.01066 | TF:M09881 | Factor: C/EBPbeta; motif: NRTTRYGCAATN | 2082 | 70 |
| 0.01066 | TF:M10858 | Factor: En-2; motif: NTCRTTARN | 7052 | 189 |
| 0.01072 | TF:M03952 | Factor: CDP; motif: TRATCRATAN | 3339 | 102 |
| 0.01072 | TF:M07450 | Factor: HOXA9; motif: DTGATTTATKGY | 3623 | 109 |
| 0.01119 | TF:M00349 | Factor: GATA-2; motif: ASAGATAANA | 3143 | 97 |
| 0.01119 | TF:M02097 | Factor: LHX3; motif: ATTAAW | 9128 | 234 |
| 0.01122 | TF:M10864 | Factor: EVX1; motif: NTCATTAN | 4124 | 121 |
| 0.01122 | TF:M03842 | Factor: POU3F1; motif: RNYBCATTTGCATTWCAA | 4041 | 119 |
| 0.01187 | TF:M02026 | Factor: MEF-2D; motif: WAAATAR | 5876 | 162 |
| 0.01192 | TF:M00423_1 | Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 | 2095 | 70 |
| 0.01211 | TF:M03549_1 | Factor: GATA-4; motif: AGATAAN; match class: 1 | 739 | 32 |
| 0.01223 | TF:M09624 | Factor: GATA-6; motif: NNNAGATAAGAWAN | 2444 | 79 |
| 0.01223 | TF:M03559_1 | Factor: Pit-1; motif: NNWWATTCAT; match class: 1 | 1042 | 41 |
| 0.01226 | TF:M12041_1 | Factor: TEF-1; motif: CRCATWCCN; match class: 1 | 519 | 25 |
| 0.01229 | TF:M11000 | Factor: LIM-1; motif: NYAATTAN | 4514 | 130 |
| 0.01246 | TF:M04360 | Factor: HOXD11; motif: NNYMATAAAA | 3768 | 112 |
| 0.01285 | TF:M11908 | Factor: POU3F2; motif: TAATKAGNNNNTAATKA | 2843 | 89 |
| 0.01317 | TF:M01883 | Factor: IRF-4; motif: GAAARTA | 6378 | 173 |
| 0.01317 | TF:M08775 | Factor: IRF-2; motif: NAANYGAAASYR | 6466 | 175 |
| 0.01372 | TF:M02909 | Factor: Sox-4; motif: NNNNNAATTGTTNNNNN | 3412 | 103 |
| 0.01372 | TF:M01230 | Factor: ZNF333; motif: ATAAT | 11903 | 290 |
| 0.01416 | TF:M10852 | Factor: Cdx-1; motif: NGTCGTAAAWN | 1626 | 57 |
| 0.01416 | TF:M03581_1 | Factor: TBP; motif: NGNNTATAAAA; match class: 1 | 1517 | 54 |
| 0.01416 | TF:M03854_1 | Factor: SRY; motif: TTGTTT; match class: 1 | 7013 | 187 |
| 0.01416 | TF:M03823_1 | Factor: FOXO1A; motif: AAACAA; match class: 1 | 7013 | 187 |
| 0.01430 | TF:M11571 | Factor: HNF-3alpha; motif: YTRWGTMAATATTTRCWYWN | 3298 | 100 |
| 0.01445 | TF:M01058 | Factor: Gfi1b; motif: TAAATCACTGCW | 1338 | 49 |
| 0.01453 | TF:M07298_1 | Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 | 189 | 13 |
| 0.01453 | TF:M00102_1 | Factor: CDP; motif: NWNATCGATTANYNN; match class: 1 | 687 | 30 |
| 0.01455 | TF:M10036 | Factor: Oct3; motif: CYWTTSWNATGCAAAT | 3302 | 100 |
| 0.01482 | TF:M02006 | Factor: GATA-5; motif: TATCTN | 7024 | 187 |
| 0.01482 | TF:M08817 | Factor: HOXD13; motif: WNNAATAAWAY | 4334 | 125 |
| 0.01491 | TF:M02115 | Factor: Prx2; motif: TYAWAKTAA | 2746 | 86 |
| 0.01491 | TF:M01275_1 | Factor: ipf1; motif: CATTAR; match class: 1 | 2628 | 83 |
| 0.01494 | TF:M00802_1 | Factor: Pit-1; motif: NMTTCATAAWTATWNMNA; match class: 1 | 855 | 35 |
| 0.01624 | TF:M12333_1 | Factor: ZBTB20; motif: NNAAYGTATRKN; match class: 1 | 298 | 17 |
| 0.01625 | TF:M07457_1 | Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 | 1277 | 47 |
| 0.01677 | TF:M03216_1 | Factor: GATA-6; motif: AGATAAN; match class: 1 | 300 | 17 |
| 0.01677 | TF:M07214_1 | Factor: GATA3; motif: AGATAAGA; match class: 1 | 300 | 17 |
| 0.01677 | TF:M08765_1 | Factor: GATA-1; motif: NGATAAN; match class: 1 | 300 | 17 |
| 0.01677 | TF:M02086 | Factor: Cdx-1; motif: TTTATK | 11083 | 273 |
| 0.01677 | TF:M00789_1 | Factor: GATA; motif: WGATARN; match class: 1 | 300 | 17 |
| 0.01677 | TF:M11910_1 | Factor: POU3F2; motif: NTAATTTATGCRN; match class: 1 | 632 | 28 |
| 0.01703 | TF:M10526 | Factor: Blimp-1; motif: RRGNGAAAGNRANNN | 1834 | 62 |
| 0.01775 | TF:M04256 | Factor: FOXO1; motif: GTAAACATGTTTAC | 3006 | 92 |
| 0.01775 | TF:M11894_1 | Factor: Oct-2; motif: NNNATTATGCAW; match class: 1 | 478 | 23 |
| 0.01775 | TF:M11929 | Factor: POU3F1; motif: NTAATKWATGCNN | 5083 | 142 |
| 0.01843 | TF:M11513 | Factor: DMRT5; motif: NNNNGWTACANT | 1654 | 57 |
| 0.01883 | TF:M11921 | Factor: Brn-4; motif: NATTATGCAWGN | 1042 | 40 |
| 0.01890 | TF:M04715 | Factor: Oct-2; motif: ATTTGCA | 4921 | 138 |
| 0.01890 | TF:M00432 | Factor: TTF1; motif: ASTCAAGTRK | 4120 | 119 |
| 0.01906 | TF:M01275 | Factor: ipf1; motif: CATTAR | 6799 | 181 |
| 0.01916 | TF:M09787 | Factor: SOX13; motif: NNACAATGGNN | 513 | 24 |
| 0.01943 | TF:M04611_1 | Factor: FOXM1; motif: NAGASTGATTA; match class: 1 | 2660 | 83 |
| 0.02014 | TF:M04119 | Factor: MGA; motif: GGTGTGAAWTTTCACACC | 2 | 2 |
| 0.02014 | TF:M04119_1 | Factor: MGA; motif: GGTGTGAAWTTTCACACC; match class: 1 | 2 | 2 |
| 0.02023 | TF:M10853 | Factor: Cdx-1; motif: NGCMATAAAAC | 1154 | 43 |
| 0.02023 | TF:M11908_1 | Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 | 979 | 38 |
| 0.02031 | TF:M11584_1 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 | 742 | 31 |
| 0.02038 | TF:M04383 | Factor: LBX2; motif: CTNRANSTAATTA | 6148 | 166 |
| 0.02047 | TF:M01324_1 | Factor: BRN1; motif: NANNTATGCATAATNNA; match class: 1 | 1263 | 46 |
| 0.02069 | TF:M01878 | Factor: GATA-3; motif: AGATAA | 7808 | 203 |
| 0.02069 | TF:M00258 | Factor: ISGF-3; motif: CAGTTTCWCTTTYCC | 613 | 27 |
| 0.02109 | TF:M08768 | Factor: HOXA10; motif: RGTMGTAAAAN | 338 | 18 |
| 0.02127 | TF:M03842_1 | Factor: POU3F1; motif: RNYBCATTTGCATTWCAA; match class: 1 | 949 | 37 |
| 0.02134 | TF:M00464 | Factor: POU3F2; motif: TTATGYTAAT | 2634 | 82 |
| 0.02140 | TF:M08773 | Factor: HOXA7; motif: NYMATTAN | 3521 | 104 |
| 0.02141 | TF:M08928 | Factor: FOSB:JUND; motif: NNTNACTNATN | 4736 | 133 |
| 0.02141 | TF:M08202_1 | Factor: CDP:HOXB13; motif: SYMRTAAANATYGATY; match class: 1 | 553 | 25 |
| 0.02141 | TF:M07254_1 | Factor: Foxc1; motif: TTVYTTTNW; match class: 1 | 2015 | 66 |
| 0.02141 | TF:M11905_1 | Factor: POU3F2; motif: NTAATTTATGCGY; match class: 1 | 553 | 25 |
| 0.02141 | TF:M03950_1 | Factor: CDP; motif: ATCGATNNNNNATCRAT; match class: 1 | 1163 | 43 |
| 0.02141 | TF:M10867 | Factor: EVX2; motif: NTCRTTAN | 585 | 26 |
| 0.02141 | TF:M10726 | Factor: HOXB8; motif: NYMATTAN | 1787 | 60 |
| 0.02141 | TF:M10712 | Factor: HOXD4; motif: NYMATTAN | 3199 | 96 |
| 0.02141 | TF:M10713 | Factor: HOXD4; motif: RTCRTTAN | 2995 | 91 |
| 0.02147 | TF:M10690_1 | Factor: HOXA7; motif: GYMATTAN; match class: 1 | 4780 | 134 |
| 0.02149 | TF:M09929_1 | Factor: FOXK1; motif: TGTTTNCNNT; match class: 1 | 491 | 23 |
| 0.02152 | TF:M04281 | Factor: ALX4; motif: NTAATYNAATTAN | 554 | 25 |
| 0.02259 | TF:M02086_1 | Factor: Cdx-1; motif: TTTATK; match class: 1 | 7466 | 195 |
| 0.02260 | TF:M02025 | Factor: MEF-2C; motif: TATTTWT | 9834 | 246 |
| 0.02401 | TF:M00463 | Factor: POU3F2; motif: ATGMATWWATTCAT | 2416 | 76 |
| 0.02401 | TF:M12208 | Factor: GATA-6; motif: WGATAACGATCW | 3254 | 97 |
| 0.02401 | TF:M07378 | Factor: cdx; motif: NNTTTATNN | 995 | 38 |
| 0.02401 | TF:M11286 | Factor: Fra-1; motif: NATGAWTCAYN | 2416 | 76 |
| 0.02401 | TF:M01125 | Factor: Oct-4; motif: YWTTSTNATGCAAAT | 1574 | 54 |
| 0.02461 | TF:M08482_1 | Factor: FOXO1A:HOXA10; motif: RWMAACANCRTWAA; match class: 1 | 529 | 24 |
| 0.02484 | TF:M10816 | Factor: HOXC11; motif: NGYMATWAANN | 4001 | 115 |
| 0.02496 | TF:M00672 | Factor: TEF; motif: ATGTTWAYATAA | 4548 | 128 |
| 0.02544 | TF:M10717 | Factor: HOXC4; motif: NTMATTAN | 2819 | 86 |
| 0.02580 | TF:M11604 | Factor: LEF-1; motif: ASATCAAAG | 2861 | 87 |
| 0.02580 | TF:M09646_1 | Factor: Oct3; motif: NYWTTSWTATGCAAAT; match class: 1 | 1107 | 41 |
| 0.02598 | TF:M00980 | Factor: TBP; motif: TTTATAN | 2114 | 68 |
| 0.02598 | TF:M10707_1 | Factor: HoxA5; motif: RTCATTAN; match class: 1 | 291 | 16 |
| 0.02639 | TF:M07315 | Factor: C/EBPbeta; motif: NNTTKCNNMAN | 2310 | 73 |
| 0.02646 | TF:M01414_1 | Factor: NKX25; motif: NNANCCACTTRAAWTT; match class: 1 | 2507 | 78 |
| 0.02691 | TF:M00991 | Factor: Cdx; motif: NAYNRHNARAKTHATAAA | 2787 | 85 |
| 0.02726 | TF:M08471_1 | Factor: Fli-1:HOXB13; motif: NNCGGAARYNRTWAA; match class: 1 | 731 | 30 |
| 0.02746 | TF:M12192 | Factor: GATA-3; motif: AGATAACGATCW | 3685 | 107 |
| 0.02746 | TF:M10816_1 | Factor: HOXC11; motif: NGYMATWAANN; match class: 1 | 799 | 32 |
| 0.02790 | TF:M02265_1 | Factor: NFATc2; motif: TTTTCCA; match class: 1 | 1552 | 53 |
| 0.02790 | TF:M04288 | Factor: BARHL2; motif: NNTAATTGNN | 1404 | 49 |
| 0.02794 | TF:M11286_1 | Factor: Fra-1; motif: NATGAWTCAYN; match class: 1 | 1779 | 59 |
| 0.02794 | TF:M03874 | Factor: Hoxa9; motif: ATYAATDACATC | 1893 | 62 |
| 0.02794 | TF:M04610 | Factor: CDP; motif: NNNNWGWYMAATR | 3483 | 102 |
| 0.02794 | TF:M03548 | Factor: FOXL2; motif: TWAKACWAMTTT | 3606 | 105 |
| 0.02802 | TF:M08940_1 | Factor: C-JUN:FRA-2; motif: NNRTGAGTCAYN; match class: 1 | 602 | 26 |
| 0.02817 | TF:M10710 | Factor: HOXD4; motif: RTCRTTAN | 2636 | 81 |
| 0.02860 | TF:M11696 | Factor: MEF-2B1; motif: CCNWATWWRG | 1744 | 58 |
| 0.02860 | TF:M11600 | Factor: TCF-1; motif: ASATCAAAG | 4914 | 136 |
| 0.03015 | TF:M07076 | Factor: c-Jun:B-ATF; motif: RNWATGASTCA | 2445 | 76 |
| 0.03032 | TF:M01404_1 | Factor: HOXD13; motif: NNNYYAATAAAANNNN; match class: 1 | 639 | 27 |
| 0.03047 | TF:M07104 | Factor: JunD; motif: NRTGASTCATN | 2056 | 66 |
| 0.03047 | TF:M04082 | Factor: POU3F3; motif: WTNAATAWKNAW | 2765 | 84 |
| 0.03057 | TF:M10062 | Factor: SNF2L; motif: NMARGAAGMATN | 1903 | 62 |
| 0.03076 | TF:M01393_1 | Factor: Msx-2; motif: NNNGACYAATTAGYNNT; match class: 1 | 3089 | 92 |
| 0.03082 | TF:M10739 | Factor: HOXB2; motif: RTCATTAN | 3009 | 90 |
| 0.03082 | TF:M07476 | Factor: Lhx8; motif: TGATTG | 6985 | 183 |
| 0.03091 | TF:M07412 | Factor: C/EBPalpha; motif: ATTGCGYAAY | 2649 | 81 |
| 0.03091 | TF:M07080 | Factor: C/EBPbeta; motif: KATTGCAYMAY | 1527 | 52 |
| 0.03091 | TF:M11566 | Factor: HNF-3alpha; motif: NWRWGTMAAYAW | 2729 | 83 |
| 0.03112 | TF:M07298 | Factor: Msx-1; motif: AHAWWTSMYYCAATTAN | 1491 | 51 |
| 0.03218 | TF:M04384 | Factor: LBX2; motif: NNYAATTANN | 2814 | 85 |
| 0.03218 | TF:M08801 | Factor: C/EBPepsilon; motif: MTTDCNNMAB | 677 | 28 |
| 0.03218 | TF:M07254 | Factor: Foxc1; motif: TTVYTTTNW | 5931 | 159 |
| 0.03270 | TF:M01884 | Factor: IRF-7; motif: AAGWGAA | 8452 | 215 |
| 0.03270 | TF:M07058 | Factor: POU2F1; motif: ATTTGCATN | 2577 | 79 |
| 0.03270 | TF:M04383_1 | Factor: LBX2; motif: CTNRANSTAATTA; match class: 1 | 1874 | 61 |
| 0.03363 | TF:M07599_1 | Factor: beta-catenin; motif: CTTTGATN; match class: 1 | 1800 | 59 |
| 0.03387 | TF:M10690 | Factor: HOXA7; motif: GYMATTAN | 8274 | 211 |
| 0.03387 | TF:M10800 | Factor: HOXA10; motif: NGYMATAAANN | 2701 | 82 |
| 0.03389 | TF:M10707 | Factor: HoxA5; motif: RTCATTAN | 2305 | 72 |
| 0.03405 | TF:M09933_1 | Factor: FOXP1; motif: TNTGTTTMY; match class: 1 | 486 | 22 |
| 0.03405 | TF:M09725 | Factor: DREF; motif: CTYYCWCTTCCY | 5898 | 158 |
| 0.03438 | TF:M07319_1 | Factor: HFH2; motif: AAACAAAN; match class: 1 | 167 | 11 |
| 0.03460 | TF:M04715_1 | Factor: Oct-2; motif: ATTTGCA; match class: 1 | 1354 | 47 |
| 0.03460 | TF:M10928 | Factor: Prop-1; motif: TAATTNNRTTA | 1391 | 48 |
| 0.03464 | TF:M02085 | Factor: Bcl-6; motif: NTTYCTAGRA | 3850 | 110 |
| 0.03584 | TF:M09888 | Factor: Crx; motif: NAAGRGGATTARN | 553 | 24 |
| 0.03584 | TF:M01337_1 | Factor: HOXA3; motif: NNNNRNTAATTARY; match class: 1 | 9261 | 232 |
| 0.03589 | TF:M08202 | Factor: CDP:HOXB13; motif: SYMRTAAANATYGATY | 3114 | 92 |
| 0.03589 | TF:M00454 | Factor: MRF2; motif: AWSCACAATACNVA | 521 | 23 |
| 0.03630 | TF:M12194 | Factor: GATA-3; motif: MGATAACGATCT | 2592 | 79 |
| 0.03630 | TF:M11611 | Factor: LEF-1; motif: ASATCAAAG | 2712 | 82 |
| 0.03687 | TF:M01301 | Factor: MEF-2A; motif: YTAAAAATARCY | 963 | 36 |
| 0.03687 | TF:M10802 | Factor: HOXA10; motif: NGYMATAAANN | 2754 | 83 |
| 0.03789 | TF:M04433 | Factor: PRRX2; motif: NYAATTAN | 2438 | 75 |
| 0.03793 | TF:M04317 | Factor: EN1; motif: TAATTRSNYAATTA | 2163 | 68 |
| 0.03926 | TF:M11910 | Factor: POU3F2; motif: NTAATTTATGCRN | 3207 | 94 |
| 0.04103 | TF:M10603 | Factor: Dlx-7; motif: NTCRTTAN | 6326 | 167 |
| 0.04103 | TF:M00095 | Factor: CDP; motif: CCAATAATCGAT | 6547 | 172 |
| 0.04103 | TF:M10612 | Factor: Dlx-5; motif: NTCRTTAN | 6326 | 167 |
| 0.04132 | TF:M01425_1 | Factor: HNF-1beta; motif: NNNNGTTAACTAGNNNT; match class: 1 | 1333 | 46 |
| 0.04146 | TF:M11606 | Factor: LEF-1; motif: ASATCAAAG | 4678 | 129 |
| 0.04146 | TF:M07079 | Factor: Cdx-2; motif: NNGYMATAAAA | 1445 | 49 |
| 0.04163 | TF:M08817_1 | Factor: HOXD13; motif: WNNAATAAWAY; match class: 1 | 1224 | 43 |
| 0.04256 | TF:M04258 | Factor: FOXO3; motif: GTAAACATGTTTAC | 2215 | 69 |
| 0.04256 | TF:M00532 | Factor: RP58; motif: NNAACATCTGGA | 313 | 16 |
| 0.04269 | TF:M01420 | Factor: Ncx; motif: NAATNAATTAATAANWW | 4386 | 122 |
| 0.04269 | TF:M08473 | Factor: FOXJ2:HOXB13; motif: TTTTATNDGNMAACA | 1263 | 44 |
| 0.04361 | TF:M04078 | Factor: POU3F2; motif: NWTGCATAAWTTA | 3018 | 89 |
| 0.04363 | TF:M04317_1 | Factor: EN1; motif: TAATTRSNYAATTA; match class: 1 | 698 | 28 |
| 0.04429 | TF:M10535 | Factor: znf136; motif: CAAGAATWCTATAYCCAG | 6385 | 168 |
| 0.04441 | TF:M08772_1 | Factor: HOXA6; motif: NYMATTAN; match class: 1 | 2025 | 64 |
| 0.04447 | TF:M01817_1 | Factor: TEF-1; motif: GWGGAATGT; match class: 1 | 345 | 17 |
| 0.04449 | TF:M07257 | Factor: HOXA10; motif: TTATNNYWN | 2900 | 86 |
| 0.04602 | TF:M10924_1 | Factor: Gscl; motif: NTAATCCN; match class: 1 | 1233 | 43 |
| 0.04684 | TF:M08520 | Factor: CDP:SRF; motif: NCCWTAYAAGGTMNKRATCRATN | 7378 | 190 |
| 0.04688 | TF:M00116 | Factor: C/EBPalpha; motif: NNATTRCNNAANNN | 2624 | 79 |
| 0.04927 | TF:M10704 | Factor: HoxA5; motif: RTCATTAN | 4195 | 117 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.04475 | CORUM:5375 | EGR-EP300 complex | 2 | 1 |
| 0.04475 | CORUM:2886 | Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial | 2 | 1 |
| 0.04475 | CORUM:3111 | ITGA9-ITGB1-SPP1 complex | 3 | 1 |
| 0.04475 | CORUM:3112 | ITGA5-ITGB1-SPP1 complex | 3 | 1 |
| 0.04475 | CORUM:3335 | NIAP homotetramer complex | 1 | 1 |
| 0.04475 | CORUM:6078 | HSPA2-ACR-PDIA6 complex | 3 | 1 |
| 0.04475 | CORUM:6616 | CADM1-4.1B-MPP3 complex | 2 | 1 |
| 0.04475 | CORUM:6230 | ULK2-ATG13-RB1CC1 complex | 3 | 1 |
| 0.04475 | CORUM:6235 | c-Fos-c-Jun-SAF-1 complex | 3 | 1 |
| 0.04475 | CORUM:6396 | DNJC3-DNAJB1-HSPA8 complex | 3 | 1 |
| 0.04475 | CORUM:6527 | FLRT3-LPHN3-UNC5B complex | 2 | 1 |
| 0.04475 | CORUM:2885 | ITGAV-ITGB1-SPP1 complex | 3 | 1 |
| 0.04475 | CORUM:6736 | PRAME-Cullin2 ubiquitin ligase complex | 2 | 1 |
| 0.04475 | CORUM:6079 | BAG6-HSPA2 complex | 2 | 1 |
| 0.04475 | CORUM:2786 | BRCA1 A complex | 3 | 1 |
| 0.04475 | CORUM:7000 | PLOD2-FKBP10 complex | 2 | 1 |
| 0.04475 | CORUM:2694 | ERG-JUN-FOS DNA-protein complex | 3 | 1 |
| 0.04475 | CORUM:790 | DDB complex | 2 | 1 |
| 0.04475 | CORUM:1123 | WNK1-SPAK complex | 2 | 1 |
| 0.04475 | CORUM:2242 | TGM2-HD-CALM1 complex | 2 | 1 |
| 0.04475 | CORUM:2243 | TGM2-HD complex | 2 | 1 |
| 0.04475 | CORUM:2347 | ITGAV-ITGB5-SPP1 complex | 3 | 1 |
| 0.04475 | CORUM:2695 | ETS2-FOS-JUN complex | 3 | 1 |
| 0.04475 | CORUM:2358 | ITGAV-ITGB3-SPP1 complex | 3 | 1 |
| 0.04475 | CORUM:2352 | ITGAV-ITGB6-SPP1 complex | 3 | 1 |
| 0.04475 | CORUM:2375 | FN1-TGM2 complex | 2 | 1 |
| 0.04475 | CORUM:6738 | PRAME-ElonginBC ubiquitin ligase | 2 | 1 |
| 0.04475 | CORUM:2693 | NFAT-JUN-FOS DNA-protein complex | 3 | 1 |
| 0.04475 | CORUM:2373 | ITGAV-ITGB3-SPP1 complex | 3 | 1 |
| 0.04788 | CORUM:2376 | ITGA2B-ITGB3-FN1-TGM2 complex | 4 | 1 |
| 0.04788 | CORUM:2383 | ITGA5-ITGB1-FN1-TGM2 complex | 4 | 1 |
| 0.04788 | CORUM:6255 | MICOS complex | 4 | 1 |
| 0.04788 | CORUM:6337 | Amot-cadherin-11-beta-catenin-p120 complex | 4 | 1 |
| 0.04788 | CORUM:1162 | Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) | 4 | 1 |
| 0.04788 | CORUM:2787 | BRCA1 C complex | 4 | 1 |
| 0.04788 | CORUM:2692 | SMAD3-SMAD4-cJun-cFos complex | 4 | 1 |
| 0.00000 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 35 | 11 |
| 0.00001 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 164 | 12 |
| 0.00002 | GO:0007416 | synapse assembly | 117 | 10 |
| 0.00004 | GO:0034329 | cell junction assembly | 333 | 15 |
| 0.00007 | GO:0007155 | cell adhesion | 1050 | 26 |
| 0.00007 | GO:0022610 | biological adhesion | 1056 | 26 |
| 0.00020 | GO:0098609 | cell-cell adhesion | 634 | 19 |
| 0.00245 | GO:0034330 | cell junction organization | 492 | 15 |
| 0.00752 | GO:0050808 | synapse organization | 248 | 10 |
| 0.02894 | GO:0010633 | negative regulation of epithelial cell migration | 97 | 6 |
| 0.01871 | MIRNA:hsa-miR-155-5p | hsa-miR-155-5p | 791 | 19 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00154 | GO:0005887 | integral component of plasma membrane | 1353 | 79 |
| 0.00154 | GO:0031226 | intrinsic component of plasma membrane | 1419 | 82 |
| 0.01347 | GO:0071944 | cell periphery | 4545 | 202 |
| 0.00741 | MIRNA:hsa-miR-335-5p | hsa-miR-335-5p | 2166 | 115 |
| 0.00016 | TF:M01010_1 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 | 2423 | 135 |
| 0.00112 | TF:M10088 | Factor: TBP; motif: MTATAAAARS | 3740 | 182 |
| 0.00112 | TF:M02087_1 | Factor: CDX-2; motif: TTTATN; match class: 1 | 3834 | 186 |
| 0.00112 | TF:M03546_1 | Factor: Dlx-5; motif: AATTAN; match class: 1 | 4449 | 209 |
| 0.00112 | TF:M01654_1 | Factor: DRI1; motif: AATTAA; match class: 1 | 4449 | 209 |
| 0.00112 | TF:M01010 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN | 6335 | 281 |
| 0.00112 | TF:M12193 | Factor: GATA-3; motif: AGATAAGATCT | 4849 | 226 |
| 0.00230 | TF:M02097_1 | Factor: LHX3; motif: ATTAAW; match class: 1 | 5026 | 229 |
| 0.00282 | TF:M04360_1 | Factor: HOXD11; motif: NNYMATAAAA; match class: 1 | 796 | 54 |
| 0.00414 | TF:M02087 | Factor: CDX-2; motif: TTTATN | 7660 | 323 |
| 0.00471 | TF:M04073 | Factor: POU2F2; motif: NWTRMATATKCAWN | 3151 | 154 |
| 0.00539 | TF:M01884_1 | Factor: IRF-7; motif: AAGWGAA; match class: 1 | 3517 | 168 |
| 0.00971 | TF:M04557 | Factor: SRY; motif: TCAATAMCATTGA | 7715 | 322 |
| 0.00971 | TF:M01878_1 | Factor: GATA-3; motif: AGATAA; match class: 1 | 3211 | 154 |
| 0.00971 | TF:M01124_1 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 | 1377 | 78 |
| 0.00971 | TF:M04555_1 | Factor: SRY; motif: AACAATANCATTGTT; match class: 1 | 2638 | 131 |
| 0.00975 | TF:M03581_1 | Factor: TBP; motif: NGNNTATAAAA; match class: 1 | 1517 | 84 |
| 0.01096 | TF:M01230_1 | Factor: ZNF333; motif: ATAAT; match class: 1 | 8866 | 361 |
| 0.01126 | TF:M02112_1 | Factor: OC-2; motif: TCAATA; match class: 1 | 1832 | 97 |
| 0.01210 | TF:M01694 | Factor: YY2; motif: CCATTWN | 1909 | 100 |
| 0.01285 | TF:M10853 | Factor: Cdx-1; motif: NGCMATAAAAC | 1154 | 67 |
| 0.01285 | TF:M07204_1 | Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 | 740 | 48 |
| 0.01285 | TF:M11585_1 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 | 1044 | 62 |
| 0.01285 | TF:M03559_1 | Factor: Pit-1; motif: NNWWATTCAT; match class: 1 | 1042 | 62 |
| 0.01324 | TF:M12041_1 | Factor: TEF-1; motif: CRCATWCCN; match class: 1 | 519 | 37 |
| 0.01438 | TF:M07270_1 | Factor: TEF-3; motif: GNTATTTTT; match class: 1 | 3445 | 161 |
| 0.01629 | TF:M00148_1 | Factor: SRY; motif: AAACWAM; match class: 1 | 3353 | 157 |
| 0.01751 | TF:M00252 | Factor: TATA; motif: STATAAAWRNNNNNN | 3546 | 164 |
| 0.01751 | TF:M00346 | Factor: GATA-1; motif: NCWGATAACA | 3388 | 158 |
| 0.01751 | TF:M01292_1 | Factor: HOXA13; motif: ATAAMA; match class: 1 | 6372 | 270 |
| 0.01751 | TF:M10535_1 | Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 | 1969 | 101 |
| 0.02051 | TF:M02112 | Factor: OC-2; motif: TCAATA | 5787 | 248 |
| 0.02052 | TF:M08836_1 | Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 | 619 | 41 |
| 0.02256 | TF:M12195 | Factor: GATA-3; motif: MGATAASATCT | 2956 | 140 |
| 0.02462 | TF:M04557_1 | Factor: SRY; motif: TCAATAMCATTGA; match class: 1 | 3784 | 172 |
| 0.02670 | TF:M03581 | Factor: TBP; motif: NGNNTATAAAA | 5412 | 233 |
| 0.02670 | TF:M01883_1 | Factor: IRF-4; motif: GAAARTA; match class: 1 | 2297 | 113 |
| 0.02797 | TF:M11899 | Factor: Oct-2; motif: NTGCATATGCAN | 4247 | 189 |
| 0.02797 | TF:M04073_1 | Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 | 1865 | 95 |
| 0.02797 | TF:M11908_1 | Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 | 979 | 57 |
| 0.02861 | TF:M07457_1 | Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 | 1277 | 70 |
| 0.02914 | TF:M10801 | Factor: HOXA10; motif: NRTCGTAAANN | 2987 | 140 |
| 0.02914 | TF:M11585 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN | 4231 | 188 |
| 0.02914 | TF:M04609 | Factor: AP-3; motif: TKGAAAKN | 3345 | 154 |
| 0.03151 | TF:M11908 | Factor: POU3F2; motif: TAATKAGNNNNTAATKA | 2843 | 134 |
| 0.03205 | TF:M02909_1 | Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 | 707 | 44 |
| 0.03205 | TF:M04235 | Factor: FOXC2; motif: NGTMAATATTKACN | 359 | 27 |
| 0.03205 | TF:M04068 | Factor: POU1F1; motif: NNNATGMATAWTTAATN | 2673 | 127 |
| 0.03205 | TF:M00026 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN | 815 | 49 |
| 0.03752 | TF:M07230 | Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG | 2861 | 134 |
| 0.03773 | TF:M08836 | Factor: OCT-2; motif: ATGMATATGCWAAT | 2812 | 132 |
| 0.03882 | TF:M04556 | Factor: SRY; motif: AACAATNNNCATTGTT | 6044 | 254 |
| 0.03882 | TF:M00423_1 | Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 | 2095 | 103 |
| 0.03882 | TF:M10707_1 | Factor: HoxA5; motif: RTCATTAN; match class: 1 | 291 | 23 |
| 0.03882 | TF:M03549_1 | Factor: GATA-4; motif: AGATAAN; match class: 1 | 739 | 45 |
| 0.03882 | TF:M01124 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN | 4669 | 203 |
| 0.03894 | TF:M00102 | Factor: CDP; motif: NWNATCGATTANYNN | 3127 | 144 |
| 0.03960 | TF:M00133_1 | Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 | 1008 | 57 |
| 0.04018 | TF:M02079_1 | Factor: Isl2; motif: CTAATKR; match class: 1 | 897 | 52 |
| 0.04069 | TF:M03813_1 | Factor: BRN1; motif: HAATGCN; match class: 1 | 5433 | 231 |
| 0.04069 | TF:M10701 | Factor: HOXB5; motif: GTCATTAN | 4572 | 199 |
| 0.04219 | TF:M00423 | Factor: FOXJ2; motif: AYMATAATATTTKN | 5302 | 226 |
| 0.04270 | TF:M04555 | Factor: SRY; motif: AACAATANCATTGTT | 5414 | 230 |
| 0.04270 | TF:M00407 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN | 1060 | 59 |
| 0.04408 | TF:M01255 | Factor: ipf1; motif: RNWCATTAANWN | 3048 | 140 |
| 0.04408 | TF:M10858 | Factor: En-2; motif: NTCRTTARN | 7052 | 289 |
| 0.04408 | TF:M00789_1 | Factor: GATA; motif: WGATARN; match class: 1 | 300 | 23 |
| 0.04408 | TF:M03216_1 | Factor: GATA-6; motif: AGATAAN; match class: 1 | 300 | 23 |
| 0.04408 | TF:M07214_1 | Factor: GATA3; motif: AGATAAGA; match class: 1 | 300 | 23 |
| 0.04408 | TF:M00351 | Factor: GATA-3; motif: ANAGATMWWA | 2046 | 100 |
| 0.04408 | TF:M08765_1 | Factor: GATA-1; motif: NGATAAN; match class: 1 | 300 | 23 |
| 0.04408 | TF:M07298_1 | Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 | 189 | 17 |
| 0.04408 | TF:M00347 | Factor: GATA-1; motif: MNAGATAANR | 3465 | 156 |
| 0.04408 | TF:M03548_1 | Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 | 772 | 46 |
| 0.04408 | TF:M10701_1 | Factor: HOXB5; motif: GTCATTAN; match class: 1 | 1068 | 59 |
| 0.04408 | TF:M10713 | Factor: HOXD4; motif: RTCRTTAN | 2995 | 138 |
| 0.04874 | TF:M07457 | Factor: Hoxa9; motif: NTTAAWTAMA | 3630 | 162 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00000 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 35 | 13 |
| 0.00000 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 164 | 17 |
| 0.00013 | GO:0007155 | cell adhesion | 1050 | 35 |
| 0.00013 | GO:0098609 | cell-cell adhesion | 634 | 26 |
| 0.00013 | GO:0022610 | biological adhesion | 1056 | 35 |
| 0.00015 | GO:0007416 | synapse assembly | 117 | 11 |
| 0.00015 | GO:0034329 | cell junction assembly | 333 | 18 |
| 0.00696 | GO:0120163 | negative regulation of cold-induced thermogenesis | 43 | 6 |
| 0.00733 | GO:0034330 | cell junction organization | 492 | 19 |
| 0.01108 | GO:0098916 | anterograde trans-synaptic signaling | 473 | 18 |
| 0.01108 | GO:0007268 | chemical synaptic transmission | 473 | 18 |
| 0.01108 | GO:0032501 | multicellular organismal process | 5090 | 93 |
| 0.01172 | GO:0099537 | trans-synaptic signaling | 478 | 18 |
| 0.01794 | GO:0099536 | synaptic signaling | 497 | 18 |
| 0.01945 | GO:0050808 | synapse organization | 248 | 12 |
| 0.02462 | GO:0030336 | negative regulation of cell migration | 256 | 12 |
| 0.03431 | GO:2000146 | negative regulation of cell motility | 267 | 12 |
| 0.03483 | GO:0014912 | negative regulation of smooth muscle cell migration | 23 | 4 |
| 0.03504 | GO:0048856 | anatomical structure development | 3824 | 72 |
| 0.03581 | GO:0051271 | negative regulation of cellular component movement | 273 | 12 |
| 0.04704 | GO:0090136 | epithelial cell-cell adhesion | 11 | 3 |
| 0.04704 | GO:0007275 | multicellular organism development | 3397 | 65 |
| 0.04824 | GO:0014909 | smooth muscle cell migration | 49 | 5 |
| 0.04824 | GO:0034332 | adherens junction organization | 48 | 5 |
| 0.04824 | GO:0040013 | negative regulation of locomotion | 291 | 12 |
| 0.04824 | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 104 | 7 |
| 0.04824 | GO:0007399 | nervous system development | 1503 | 35 |
| 0.04881 | GO:0002689 | negative regulation of leukocyte chemotaxis | 12 | 3 |
| 0.04940 | GO:0018916 | nitrobenzene metabolic process | 3 | 2 |
| 0.04940 | GO:0051410 | detoxification of nitrogen compound | 3 | 2 |
| 0.04940 | GO:0071603 | endothelial cell-cell adhesion | 3 | 2 |
| 0.04940 | GO:0070458 | cellular detoxification of nitrogen compound | 3 | 2 |
| 0.01474 | GO:0016342 | catenin complex | 32 | 5 |
| 0.01474 | GO:0071944 | cell periphery | 4545 | 84 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.01719 | GO:0031226 | intrinsic component of plasma membrane | 1419 | 70 |
| 0.02059 | GO:0005887 | integral component of plasma membrane | 1353 | 66 |
| 0.01780 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 1193 | 61 |
| 0.01780 | GO:0003700 | DNA-binding transcription factor activity | 1231 | 62 |
| 0.01780 | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 1206 | 61 |
| 0.01956 | GO:0000976 | transcription cis-regulatory region binding | 1292 | 63 |
| 0.01956 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 1031 | 53 |
| 0.01956 | GO:0001067 | transcription regulatory region nucleic acid binding | 1293 | 63 |
| 0.02245 | GO:0000987 | cis-regulatory region sequence-specific DNA binding | 1045 | 53 |
| 0.02521 | GO:1990837 | sequence-specific double-stranded DNA binding | 1351 | 64 |
| 0.02521 | GO:0008009 | chemokine activity | 42 | 7 |
| 0.03498 | GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | 143 | 13 |
| 0.03498 | GO:0150100 | RNA binding involved in posttranscriptional gene silencing | 143 | 13 |
| 0.03747 | GO:0003690 | double-stranded DNA binding | 1413 | 65 |
| 0.03798 | GO:0043565 | sequence-specific DNA binding | 1418 | 65 |
| 0.04239 | GO:0038102 | activin receptor antagonist activity | 2 | 2 |
| 0.04239 | GO:0015276 | ligand-gated ion channel activity | 118 | 11 |
| 0.04239 | GO:0022834 | ligand-gated channel activity | 118 | 11 |
| 0.04239 | GO:0004917 | interleukin-7 receptor activity | 2 | 2 |
| 0.04239 | GO:0015318 | inorganic molecular entity transmembrane transporter activity | 577 | 32 |
| 0.04239 | GO:0022890 | inorganic cation transmembrane transporter activity | 474 | 28 |
| 0.04239 | GO:0099094 | ligand-gated cation channel activity | 97 | 10 |
| 0.04906 | GO:0042379 | chemokine receptor binding | 54 | 7 |
| 0.04906 | GO:0008324 | cation transmembrane transporter activity | 517 | 29 |
| 0.01833 | MIRNA:hsa-miR-335-5p | hsa-miR-335-5p | 2166 | 100 |
| 0.01530 | REAC:R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 296 | 23 |
| 0.01530 | REAC:R-HSA-500792 | GPCR ligand binding | 419 | 29 |
| 0.00027 | TF:M01010_1 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 | 2423 | 119 |
| 0.00053 | TF:M10088 | Factor: TBP; motif: MTATAAAARS | 3740 | 163 |
| 0.00053 | TF:M02087_1 | Factor: CDX-2; motif: TTTATN; match class: 1 | 3834 | 166 |
| 0.00230 | TF:M02087 | Factor: CDX-2; motif: TTTATN | 7660 | 285 |
| 0.00267 | TF:M01010 | Factor: HMGIY; motif: NNKKNAWTTTNYTNN | 6335 | 243 |
| 0.00267 | TF:M02097_1 | Factor: LHX3; motif: ATTAAW; match class: 1 | 5026 | 201 |
| 0.00371 | TF:M04073 | Factor: POU2F2; motif: NWTRMATATKCAWN | 3151 | 137 |
| 0.00702 | TF:M10853 | Factor: Cdx-1; motif: NGCMATAAAAC | 1154 | 62 |
| 0.00702 | TF:M03546_1 | Factor: Dlx-5; motif: AATTAN; match class: 1 | 4449 | 178 |
| 0.00702 | TF:M01654_1 | Factor: DRI1; motif: AATTAA; match class: 1 | 4449 | 178 |
| 0.00702 | TF:M12193 | Factor: GATA-3; motif: AGATAAGATCT | 4849 | 192 |
| 0.00702 | TF:M01124_1 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 | 1377 | 70 |
| 0.00702 | TF:M04557_1 | Factor: SRY; motif: TCAATAMCATTGA; match class: 1 | 3784 | 156 |
| 0.00702 | TF:M04557 | Factor: SRY; motif: TCAATAMCATTGA | 7715 | 281 |
| 0.00702 | TF:M01694 | Factor: YY2; motif: CCATTWN | 1909 | 90 |
| 0.00832 | TF:M00252 | Factor: TATA; motif: STATAAAWRNNNNNN | 3546 | 147 |
| 0.00832 | TF:M01884_1 | Factor: IRF-7; motif: AAGWGAA; match class: 1 | 3517 | 146 |
| 0.00897 | TF:M12041_1 | Factor: TEF-1; motif: CRCATWCCN; match class: 1 | 519 | 34 |
| 0.00897 | TF:M04360_1 | Factor: HOXD11; motif: NNYMATAAAA; match class: 1 | 796 | 46 |
| 0.00897 | TF:M03581 | Factor: TBP; motif: NGNNTATAAAA | 5412 | 208 |
| 0.01291 | TF:M07204_1 | Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 | 740 | 43 |
| 0.01291 | TF:M00407 | Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN | 1060 | 56 |
| 0.01636 | TF:M04073_1 | Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 | 1865 | 86 |
| 0.01814 | TF:M07270_1 | Factor: TEF-3; motif: GNTATTTTT; match class: 1 | 3445 | 141 |
| 0.02169 | TF:M10535_1 | Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 | 1969 | 89 |
| 0.02169 | TF:M08918_1 | Factor: GATA-3; motif: WGATAASN; match class: 1 | 505 | 32 |
| 0.02169 | TF:M03997_1 | Factor: GATA3; motif: NGATAANN; match class: 1 | 505 | 32 |
| 0.02236 | TF:M00026 | Factor: RSRFC4; motif: RNKCTATTTWTAGMWN | 815 | 45 |
| 0.02350 | TF:M03581_1 | Factor: TBP; motif: NGNNTATAAAA; match class: 1 | 1517 | 72 |
| 0.02350 | TF:M11585_1 | Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 | 1044 | 54 |
| 0.02509 | TF:M02112 | Factor: OC-2; motif: TCAATA | 5787 | 216 |
| 0.02579 | TF:M00351 | Factor: GATA-3; motif: ANAGATMWWA | 2046 | 91 |
| 0.02750 | TF:M08765_1 | Factor: GATA-1; motif: NGATAAN; match class: 1 | 300 | 22 |
| 0.02750 | TF:M00789_1 | Factor: GATA; motif: WGATARN; match class: 1 | 300 | 22 |
| 0.02750 | TF:M10092_1 | Factor: TEF-1; motif: RCATTCCWGNNN; match class: 1 | 237 | 19 |
| 0.02750 | TF:M07214_1 | Factor: GATA3; motif: AGATAAGA; match class: 1 | 300 | 22 |
| 0.02750 | TF:M03216_1 | Factor: GATA-6; motif: AGATAAN; match class: 1 | 300 | 22 |
| 0.03068 | TF:M08836 | Factor: OCT-2; motif: ATGMATATGCWAAT | 2812 | 117 |
| 0.03068 | TF:M04555_1 | Factor: SRY; motif: AACAATANCATTGTT; match class: 1 | 2638 | 111 |
| 0.03068 | TF:M07457_1 | Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 | 1277 | 62 |
| 0.03454 | TF:M01058 | Factor: Gfi1b; motif: TAAATCACTGCW | 1338 | 64 |
| 0.03454 | TF:M00148_1 | Factor: SRY; motif: AAACWAM; match class: 1 | 3353 | 135 |
| 0.03462 | TF:M02079_1 | Factor: Isl2; motif: CTAATKR; match class: 1 | 897 | 47 |
| 0.03561 | TF:M02112_1 | Factor: OC-2; motif: TCAATA; match class: 1 | 1832 | 82 |
| 0.03657 | TF:M07278 | Factor: Dlx-3; motif: NTAATTNVN | 2716 | 113 |
| 0.03669 | TF:M02026_1 | Factor: MEF-2D; motif: WAAATAR; match class: 1 | 1864 | 83 |
| 0.03805 | TF:M00133_1 | Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 | 1008 | 51 |
| 0.03805 | TF:M00423 | Factor: FOXJ2; motif: AYMATAATATTTKN | 5302 | 198 |
| 0.03805 | TF:M03858_1 | Factor: TCF-3; motif: CTTTGA; match class: 1 | 4222 | 163 |
| 0.03805 | TF:M11899 | Factor: Oct-2; motif: NTGCATATGCAN | 4247 | 164 |
| 0.03805 | TF:M00805_1 | Factor: TCF-7; motif: TCAAAG; match class: 1 | 4222 | 163 |
| 0.03805 | TF:M02909_1 | Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 | 707 | 39 |
| 0.03805 | TF:M00136 | Factor: Oct-1; motif: NNGAATATKCANNNN | 3225 | 130 |
| 0.03860 | TF:M04235 | Factor: FOXC2; motif: NGTMAATATTKACN | 359 | 24 |
| 0.03982 | TF:M08836_1 | Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 | 619 | 35 |
| 0.03982 | TF:M07079 | Factor: Cdx-2; motif: NNGYMATAAAA | 1445 | 67 |
| 0.03982 | TF:M03549_1 | Factor: GATA-4; motif: AGATAAN; match class: 1 | 739 | 40 |
| 0.03982 | TF:M01124 | Factor: Oct-4; motif: ATTGWSWTGCWAAWN | 4669 | 177 |
| 0.03982 | TF:M10797 | Factor: HOXA10; motif: RGTCGTAAAAN | 4269 | 164 |
| 0.03982 | TF:M04556 | Factor: SRY; motif: AACAATNNNCATTGTT | 6044 | 221 |
| 0.03982 | TF:M01723_1 | Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 | 385 | 25 |
| 0.03982 | TF:M03559_1 | Factor: Pit-1; motif: NNWWATTCAT; match class: 1 | 1042 | 52 |
| 0.03982 | TF:M00102 | Factor: CDP; motif: NWNATCGATTANYNN | 3127 | 126 |
| 0.04025 | TF:M01292_1 | Factor: HOXA13; motif: ATAAMA; match class: 1 | 6372 | 231 |
| 0.04338 | TF:M01149 | Factor: DMRT4; motif: AATGTADCAAWTT | 1398 | 65 |
| 0.04375 | TF:M07364_1 | Factor: NF-1; motif: TTGGCNN; match class: 1 | 552 | 32 |
| 0.04375 | TF:M11894 | Factor: Oct-2; motif: NNNATTATGCAW | 2844 | 116 |
Now we isolate the genes that are up or down regulated in just one subgroup.
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00237 | CORUM:1439 | PTGS2 homodimer complex | 1 | 1 |
| 0.04900 | HP:0010243 | Abnormality of the epiphyses of the distal phalanx of finger | 1 | 1 |
| 0.04900 | HP:0010237 | Epiphyseal stippling of finger phalanges | 1 | 1 |
| 0.04900 | HP:0010038 | Short 2nd metacarpal | 2 | 1 |
| 0.04900 | HP:0009850 | Triangular shaped middle phalanges of the hand | 2 | 1 |
| 0.04900 | HP:0009695 | Stippling of thumb epiphysis | 1 | 1 |
| 0.04900 | HP:0009684 | Stippling of the epiphysis of the distal phalanx of the thumb | 1 | 1 |
| 0.04900 | HP:0009662 | Abnormality of the epiphysis of the distal phalanx of the thumb | 1 | 1 |
| 0.04900 | HP:0009638 | Short proximal phalanx of thumb | 2 | 1 |
| 0.04900 | HP:0009606 | Complete duplication of distal phalanx of the thumb | 2 | 1 |
| 0.04900 | HP:0009599 | Abnormality of thumb epiphysis | 2 | 1 |
| 0.04900 | HP:0009575 | Triangular shaped middle phalanx of the 2nd finger | 2 | 1 |
| 0.04900 | HP:0009566 | Short distal phalanx of the 2nd finger | 2 | 1 |
| 0.04900 | HP:0009557 | Aplasia/Hypoplasia of the distal phalanx of the 2nd finger | 2 | 1 |
| 0.04900 | HP:0009546 | Triangular shaped phalanges of the 2nd finger | 2 | 1 |
| 0.04900 | HP:0009495 | Pseudoepiphyses of the 2nd finger | 1 | 1 |
| 0.04900 | HP:0009378 | Triangular shaped phalanges of the 5th finger | 2 | 1 |
| 0.04900 | HP:0009373 | Type C brachydactyly | 1 | 1 |
| 0.04900 | HP:0009372 | Type A2 brachydactyly | 2 | 1 |
| 0.04900 | HP:0009182 | Triangular shaped middle phalanx of the 5th finger | 2 | 1 |
| 0.04900 | HP:0008096 | Medially deviated second toe | 2 | 1 |
| 0.04900 | HP:0006263 | Abnormality of the epiphyses of the 2nd finger | 1 | 1 |
| 0.04900 | HP:0005028 | Widened proximal tibial metaphyses | 2 | 1 |
| 0.04900 | HP:0010255 | Stippling of the epiphyses of the distal phalanges of the hand | 1 | 1 |
| 0.04900 | HP:0100387 | Aplasia of the middle phalanges of the toes | 1 | 1 |
| 0.04370 | TF:M01185 | Factor: BCL-6; motif: WRCTTTCKAGGRAT | 4666 | 15 |
We have not identified any down regulated gene expressed just in G3 subgroup.
We have not identified any up regulated gene expressed just in G4 subgroup.
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00150 | CORUM:6079 | BAG6-HSPA2 complex | 2 | 1 |
| 0.00150 | CORUM:6736 | PRAME-Cullin2 ubiquitin ligase complex | 2 | 1 |
| 0.00150 | CORUM:6738 | PRAME-ElonginBC ubiquitin ligase | 2 | 1 |
| 0.00168 | CORUM:6078 | HSPA2-ACR-PDIA6 complex | 3 | 1 |
| 0.00225 | CORUM:7556 | PRAME complex | 5 | 1 |
| 0.04135 | WP:WP3888 | VEGFA-VEGFR2 Signaling Pathway | 389 | 2 |
| 0.04994 | WP:WP4932 | 7q11.23 copy number variation syndrome | 81 | 1 |
| 0.04994 | WP:WP2359 | Parkin-Ubiquitin Proteasomal System pathway | 61 | 1 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.01667 | CORUM:7289 | ANGPTL4-LRP6-SDC2 complex | 3 | 1 |
| 0.01667 | CORUM:7288 | ANGPTL4-LRP6-SDC1 complex | 3 | 1 |
| 0.01667 | CORUM:6718 | CALM1-KCNQ4(splice variant 1) complex | 1 | 1 |
| 0.01667 | CORUM:6440 | CHRNA2-CHRNB4 complex | 2 | 1 |
| 0.01667 | CORUM:5748 | 2AR-mGluR2 complex | 2 | 1 |
| 0.01667 | CORUM:5747 | 2AR-mGluR2 complex | 2 | 1 |
| 0.01667 | CORUM:7290 | ANGPTL4-LRP6-SDC4 complex | 3 | 1 |
| 0.01667 | CORUM:595 | Kv4.2-DPP10 channel complex | 2 | 1 |
| 0.01972 | CORUM:2754 | JUND-FOSB-SMAD3-SMAD4 complex | 4 | 1 |
| 0.05000 | GO:0071881 | adenylate cyclase-inhibiting adrenergic receptor signaling pathway | 4 | 2 |
| 0.05000 | GO:0060084 | synaptic transmission involved in micturition | 3 | 2 |
| 0.05000 | GO:0060073 | micturition | 4 | 2 |
| 0.03788 | REAC:R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors | 13 | 2 |
| 0.03788 | REAC:R-HSA-629587 | Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | 6 | 2 |
| 0.03788 | REAC:R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | 11 | 2 |
| 0.03788 | REAC:R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors | 9 | 2 |
| 0.03788 | REAC:R-HSA-181431 | Acetylcholine binding and downstream events | 13 | 2 |
| 0.03788 | REAC:R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors | 11 | 2 |
| 0.00716 | WP:WP1603 | Nicotine Activity on Chromaffin Cells | 4 | 2 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.03295 | GO:0004143 | diacylglycerol kinase activity | 11 | 1 |
| 0.01297 | HPA:0260142 | hypothalamus; neuronal projections[=Medium] | 25 | 1 |
| 0.01297 | HPA:0260131 | hypothalamus; neuronal cells[=Low] | 24 | 1 |
| 0.01297 | HPA:0260141 | hypothalamus; neuronal projections[=Low] | 26 | 1 |
| 0.01310 | HPA:0260000 | hypothalamus | 35 | 1 |
| 0.02026 | KEGG:00561 | Glycerolipid metabolism | 51 | 1 |
| 0.02026 | KEGG:00564 | Glycerophospholipid metabolism | 82 | 1 |
| 0.02026 | KEGG:04070 | Phosphatidylinositol signaling system | 93 | 1 |
| 0.02026 | KEGG:05231 | Choline metabolism in cancer | 86 | 1 |
| 0.02367 | KEGG:04072 | Phospholipase D signaling pathway | 136 | 1 |
| 0.02187 | MIRNA:hsa-miR-95-5p | hsa-miR-95-5p | 110 | 1 |
| 0.02187 | MIRNA:hsa-miR-7-2-3p | hsa-miR-7-2-3p | 139 | 1 |
| 0.02187 | MIRNA:hsa-miR-7-1-3p | hsa-miR-7-1-3p | 150 | 1 |
| 0.02187 | MIRNA:hsa-miR-495-3p | hsa-miR-495-3p | 154 | 1 |
| 0.02187 | MIRNA:hsa-miR-551b-5p | hsa-miR-551b-5p | 131 | 1 |
| 0.02187 | MIRNA:hsa-miR-3121-3p | hsa-miR-3121-3p | 119 | 1 |
| 0.02187 | MIRNA:hsa-miR-5688 | hsa-miR-5688 | 141 | 1 |
| 0.02695 | REAC:R-HSA-114508 | Effects of PIP2 hydrolysis | 27 | 1 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.01517 | GO:1900449 | regulation of glutamate receptor signaling pathway | 4 | 1 |
| 0.01517 | GO:1900451 | positive regulation of glutamate receptor signaling pathway | 1 | 1 |
| 0.01517 | GO:1904020 | regulation of G protein-coupled receptor internalization | 3 | 1 |
| 0.01517 | GO:1904021 | negative regulation of G protein-coupled receptor internalization | 2 | 1 |
| 0.01517 | GO:0035588 | G protein-coupled purinergic receptor signaling pathway | 4 | 1 |
| 0.01517 | GO:0060168 | positive regulation of adenosine receptor signaling pathway | 1 | 1 |
| 0.01517 | GO:0001973 | G protein-coupled adenosine receptor signaling pathway | 4 | 1 |
| 0.01517 | GO:0060167 | regulation of adenosine receptor signaling pathway | 2 | 1 |
| 0.03209 | GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway | 16 | 1 |
| 0.03209 | GO:0042984 | regulation of amyloid precursor protein biosynthetic process | 18 | 1 |
| 0.03209 | GO:0042983 | amyloid precursor protein biosynthetic process | 18 | 1 |
| 0.03209 | GO:0030322 | stabilization of membrane potential | 16 | 1 |
| 0.03209 | GO:0023058 | adaptation of signaling pathway | 14 | 1 |
| 0.03209 | GO:0022401 | negative adaptation of signaling pathway | 14 | 1 |
| 0.03209 | GO:0002091 | negative regulation of receptor internalization | 14 | 1 |
| 0.03209 | GO:0002031 | G protein-coupled receptor internalization | 10 | 1 |
| 0.03209 | GO:0002029 | desensitization of G protein-coupled receptor signaling pathway | 14 | 1 |
| 0.04207 | GO:0035590 | purinergic nucleotide receptor signaling pathway | 25 | 1 |
| 0.04623 | GO:0048261 | negative regulation of receptor-mediated endocytosis | 29 | 1 |
| 0.00786 | GO:0031685 | adenosine receptor binding | 2 | 1 |
| 0.00786 | GO:0031687 | A2A adenosine receptor binding | 1 | 1 |
| 0.00786 | GO:0031802 | type 5 metabotropic glutamate receptor binding | 3 | 1 |
| 0.01572 | GO:0035256 | G protein-coupled glutamate receptor binding | 8 | 1 |
| 0.01964 | GO:0035254 | glutamate receptor binding | 20 | 1 |
| 0.01964 | GO:0022842 | narrow pore channel activity | 18 | 1 |
| 0.01964 | GO:0022841 | potassium ion leak channel activity | 15 | 1 |
| 0.01964 | GO:0022840 | leak channel activity | 18 | 1 |
| 0.01435 | HP:0001848 | Calcaneovalgus deformity | 10 | 1 |
| 0.01435 | HP:0008138 | Equinus calcaneus | 5 | 1 |
| 0.01435 | HP:0008119 | Deformed tarsal bones | 10 | 1 |
| 0.02795 | HP:0008364 | Abnormality of the calcaneus | 26 | 1 |
| 0.03793 | HP:0001838 | Rocker bottom foot | 52 | 1 |
| 0.03793 | HP:0008365 | Abnormality of the talus | 53 | 1 |
| 0.00300 | REAC:R-HSA-1299361 | TWIK-related alkaline pH activated K+ channel (TALK) | 2 | 1 |
| 0.00824 | REAC:R-HSA-1296346 | Tandem pore domain potassium channels | 11 | 1 |
| 0.00848 | REAC:R-HSA-5576886 | Phase 4 - resting membrane potential | 17 | 1 |
| 0.03599 | REAC:R-HSA-5576891 | Cardiac conduction | 121 | 1 |
| 0.03599 | REAC:R-HSA-1296071 | Potassium Channels | 99 | 1 |
| 0.04542 | REAC:R-HSA-397014 | Muscle contraction | 184 | 1 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00874 | CORUM:668 | BKCA-beta2AR-AKAP79 signaling complex | 3 | 1 |
| 0.00874 | CORUM:672 | BKCA-beta2AR complex | 2 | 1 |
| 0.00874 | CORUM:2272 | PICK1-GRIP1-GLUR2 complex | 3 | 1 |
| 0.00874 | CORUM:2699 | ESR1-JUN-GRIP1 complex | 3 | 1 |
| 0.00874 | CORUM:6069 | ESR1-GRIP1 complex | 2 | 1 |
| 0.00874 | CORUM:6726 | GRASP1-GRIP1 complex | 2 | 1 |
| 0.00874 | CORUM:6748 | KCNMA1-LRRC26 complex | 1 | 1 |
| 0.00874 | CORUM:7421 | TSPY1-TSPYL5-USP7 complex | 2 | 1 |
| 0.02060 | CORUM:2919 | Respiratory chain complex I (gamma subunit) mitochondrial | 8 | 1 |
| 0.02126 | GO:0035259 | glucocorticoid receptor binding | 8 | 2 |
| 0.02353 | REAC:R-HSA-2022923 | Dermatan sulfate biosynthesis | 11 | 2 |
| p_value | term_id | term_name | term_size | intersection_size |
|---|---|---|---|---|
| 0.00749 | GO:0005003 | ephrin receptor activity | 15 | 1 |
| 0.00749 | GO:0005005 | transmembrane-ephrin receptor activity | 15 | 1 |
| 0.01923 | GO:0019199 | transmembrane receptor protein kinase activity | 77 | 1 |
| 0.01923 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 59 | 1 |
| 0.02177 | GO:0004713 | protein tyrosine kinase activity | 109 | 1 |
| 0.02210 | KEGG:04360 | Axon guidance | 177 | 1 |
| 0.01449 | MIRNA:hsa-miR-4290 | hsa-miR-4290 | 76 | 1 |
| 0.01449 | MIRNA:hsa-miR-3675-3p | hsa-miR-3675-3p | 125 | 1 |
| 0.01449 | MIRNA:hsa-miR-216b-5p | hsa-miR-216b-5p | 113 | 1 |
| 0.01449 | MIRNA:hsa-miR-6779-3p | hsa-miR-6779-3p | 54 | 1 |
| 0.01449 | MIRNA:hsa-miR-4762-5p | hsa-miR-4762-5p | 112 | 1 |
| 0.01449 | MIRNA:hsa-miR-519d-5p | hsa-miR-519d-5p | 123 | 1 |
| 0.01449 | MIRNA:hsa-miR-520f-5p | hsa-miR-520f-5p | 60 | 1 |
| 0.01656 | MIRNA:hsa-miR-4667-3p | hsa-miR-4667-3p | 204 | 1 |
| 0.01656 | MIRNA:hsa-miR-4691-5p | hsa-miR-4691-5p | 197 | 1 |
| 0.01656 | MIRNA:hsa-miR-6792-3p | hsa-miR-6792-3p | 198 | 1 |
| 0.01756 | MIRNA:hsa-miR-5193 | hsa-miR-5193 | 238 | 1 |
| 0.01948 | MIRNA:hsa-miR-18a-3p | hsa-miR-18a-3p | 288 | 1 |
| 0.01049 | REAC:R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 48 | 1 |
| 0.01049 | REAC:R-HSA-3928663 | EPHA-mediated growth cone collapse | 27 | 1 |
| 0.01267 | REAC:R-HSA-2682334 | EPH-Ephrin signaling | 87 | 1 |
| 0.03968 | REAC:R-HSA-422475 | Axon guidance | 431 | 1 |
| 0.03968 | REAC:R-HSA-9675108 | Nervous system development | 454 | 1 |
We have not identified any down regulated gene expressed just in Transition subgroup.