Introduction

This file contains the enrichments of the genes selected as more relevant for the differentiation between the medulloblastoma subgroups: G3, G4, WNT and SHH. We also include here a new subgroup called Transition-G3-G4 that is the new subgroup proposed that exists between Group3 and Group4.

The enrichments are shown both with a table and a interactive plot. In addition, the enrichments are computed using all the genes of each subgroup and using the genes that are up or down expressed specifically in each subgroup, for better differentiation.

Group3 enrichments

Up Regulated Genes

p_value term_id term_name term_size intersection_size
0.00000 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 35 13
0.00002 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 164 17
0.00262 GO:0007416 synapse assembly 117 12
0.00579 GO:0007155 cell adhesion 1050 41
0.00579 GO:0022610 biological adhesion 1056 41
0.01174 GO:0034329 cell junction assembly 333 19
0.01533 GO:0007268 chemical synaptic transmission 473 23
0.01533 GO:0098916 anterograde trans-synaptic signaling 473 23
0.01604 GO:0099537 trans-synaptic signaling 478 23
0.02183 GO:0014912 negative regulation of smooth muscle cell migration 23 5
0.02183 GO:0099536 synaptic signaling 497 23
0.02183 GO:0098609 cell-cell adhesion 634 27
0.02357 GO:0032501 multicellular organismal process 5090 127
0.02852 GO:0030336 negative regulation of cell migration 256 15
0.03310 GO:0040013 negative regulation of locomotion 291 16
0.03394 GO:0120163 negative regulation of cold-induced thermogenesis 43 6
0.03736 GO:2000146 negative regulation of cell motility 267 15
0.04116 GO:0051271 negative regulation of cellular component movement 273 15
0.04116 GO:0048856 anatomical structure development 3824 99
0.04116 GO:0051241 negative regulation of multicellular organismal process 791 30
0.04729 GO:0050808 synapse organization 248 14
0.04928 GO:0050922 negative regulation of chemotaxis 49 6
0.04928 GO:0014909 smooth muscle cell migration 49 6
0.03370 GO:0071944 cell periphery 4545 116

Down Regulated Genes

p_value term_id term_name term_size intersection_size
0.03414 GO:0008009 chemokine activity 42 7
0.03414 GO:0003700 DNA-binding transcription factor activity 1231 51
0.03414 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 1193 50
0.03414 GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 1206 50
0.03522 GO:0001067 transcription regulatory region nucleic acid binding 1293 52
0.03522 GO:0000976 transcription cis-regulatory region binding 1292 52
0.03676 GO:0042379 chemokine receptor binding 54 7
0.04106 GO:0060089 molecular transducer activity 1086 44
0.04106 GO:1903231 mRNA binding involved in posttranscriptional gene silencing 143 11
0.04106 GO:0150100 RNA binding involved in posttranscriptional gene silencing 143 11
0.04106 GO:1990837 sequence-specific double-stranded DNA binding 1351 53
0.04106 GO:0038023 signaling receptor activity 1086 44
0.04106 GO:0004917 interleukin-7 receptor activity 2 2
0.04106 GO:0003690 double-stranded DNA binding 1413 54
0.04106 GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 1031 42
0.04106 GO:0038102 activin receptor antagonist activity 2 2
0.00515 REAC:R-HSA-500792 GPCR ligand binding 419 26
0.00515 REAC:R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 296 21
0.00717 REAC:R-HSA-418594 G alpha (i) signalling events 368 23
0.00717 REAC:R-HSA-388396 GPCR downstream signalling 978 45
0.00979 REAC:R-HSA-372790 Signaling by GPCR 1038 46
0.03398 REAC:R-HSA-380108 Chemokine receptors bind chemokines 53 7
0.00289 TF:M01010_1 Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 2423 95
0.00289 TF:M01010 Factor: HMGIY; motif: NNKKNAWTTTNYTNN 6335 201
0.00289 TF:M04073 Factor: POU2F2; motif: NWTRMATATKCAWN 3151 117
0.00289 TF:M10088 Factor: TBP; motif: MTATAAAARS 3740 134
0.00473 TF:M01654_1 Factor: DRI1; motif: AATTAA; match class: 1 4449 150
0.00473 TF:M03546_1 Factor: Dlx-5; motif: AATTAN; match class: 1 4449 150
0.00482 TF:M02097_1 Factor: LHX3; motif: ATTAAW; match class: 1 5026 165
0.00532 TF:M04360_1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 796 41
0.00669 TF:M01124_1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1377 60
0.00866 TF:M00252 Factor: TATA; motif: STATAAAWRNNNNNN 3546 123
0.00866 TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 3517 122
0.00866 TF:M12193 Factor: GATA-3; motif: AGATAAGATCT 4849 158
0.00990 TF:M04073_1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1865 74
0.01055 TF:M02087_1 Factor: CDX-2; motif: TTTATN; match class: 1 3834 130
0.01421 TF:M01723_1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 385 24
0.01689 TF:M01694 Factor: YY2; motif: CCATTWN 1909 74
0.01689 TF:M02087 Factor: CDX-2; motif: TTTATN 7660 227
0.01693 TF:M02079_1 Factor: Isl2; motif: CTAATKR; match class: 1 897 42
0.01693 TF:M04557_1 Factor: SRY; motif: TCAATAMCATTGA; match class: 1 3784 127
0.01792 TF:M04557 Factor: SRY; motif: TCAATAMCATTGA 7715 227
0.01792 TF:M08836_1 Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 619 32
0.01792 TF:M00351 Factor: GATA-3; motif: ANAGATMWWA 2046 77
0.01792 TF:M02112_1 Factor: OC-2; motif: TCAATA; match class: 1 1832 71
0.01792 TF:M08836 Factor: OCT-2; motif: ATGMATATGCWAAT 2812 99
0.01792 TF:M01124 Factor: Oct-4; motif: ATTGWSWTGCWAAWN 4669 150
0.01792 TF:M07278 Factor: Dlx-3; motif: NTAATTNVN 2716 97
0.01792 TF:M08520_1 Factor: CDP:SRF; motif: NCCWTAYAAGGTMNKRATCRATN; match class: 1 2461 89
0.01792 TF:M00133_1 Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 1008 45
0.01792 TF:M03581 Factor: TBP; motif: NGNNTATAAAA 5412 169
0.01792 TF:M11894 Factor: Oct-2; motif: NNNATTATGCAW 2844 100
0.01891 TF:M11585_1 Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 1044 46
0.02116 TF:M00136 Factor: Oct-1; motif: NNGAATATKCANNNN 3225 110
0.02116 TF:M02112 Factor: OC-2; motif: TCAATA 5787 178
0.02131 TF:M01255 Factor: ipf1; motif: RNWCATTAANWN 3048 105
0.02315 TF:M00026 Factor: RSRFC4; motif: RNKCTATTTWTAGMWN 815 38
0.02324 TF:M00407 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN 1060 46
0.02366 TF:M04556 Factor: SRY; motif: AACAATNNNCATTGTT 6044 184
0.02650 TF:M07270_1 Factor: TEF-3; motif: GNTATTTTT; match class: 1 3445 115
0.02650 TF:M02909_1 Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 707 34
0.02650 TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 2165 79
0.02650 TF:M00805_1 Factor: TCF-7; motif: TCAAAG; match class: 1 4222 136
0.02650 TF:M03858_1 Factor: TCF-3; motif: CTTTGA; match class: 1 4222 136
0.02650 TF:M11908_1 Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 979 43
0.02747 TF:M01149 Factor: DMRT4; motif: AATGTADCAAWTT 1398 56
0.02747 TF:M04635 Factor: TEF-5; motif: AAAAATAT 2449 87
0.02747 TF:M00102 Factor: CDP; motif: NWNATCGATTANYNN 3127 106
0.02974 TF:M00148_1 Factor: SRY; motif: AAACWAM; match class: 1 3353 112
0.03183 TF:M04556_1 Factor: SRY; motif: AACAATNNNCATTGTT; match class: 1 4704 148
0.03409 TF:M07230 Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG 2861 98
0.03487 TF:M07298_1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 189 14
0.03497 TF:M03559 Factor: Pit-1; motif: NNWWATTCAT 4039 130
0.03540 TF:M07476_1 Factor: Lhx8; motif: TGATTG; match class: 1 2337 83
0.03551 TF:M10797 Factor: HOXA10; motif: RGTCGTAAAAN 4269 136
0.03856 TF:M10801 Factor: HOXA10; motif: NRTCGTAAANN 2987 101
0.03856 TF:M00802_1 Factor: Pit-1; motif: NMTTCATAAWTATWNMNA; match class: 1 855 38
0.03952 TF:M03997_1 Factor: GATA3; motif: NGATAANN; match class: 1 505 26
0.03952 TF:M08918_1 Factor: GATA-3; motif: WGATAASN; match class: 1 505 26
0.03952 TF:M11899 Factor: Oct-2; motif: NTGCATATGCAN 4247 135
0.04050 TF:M03549_1 Factor: GATA-4; motif: AGATAAN; match class: 1 739 34
0.04276 TF:M03548_1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 772 35
0.04328 TF:M11571 Factor: HNF-3alpha; motif: YTRWGTMAATATTTRCWYWN 3298 109
0.04328 TF:M07457_1 Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 1277 51
0.04425 TF:M05611 Factor: SALL3; motif: CGAGTCTGAAK 15 4
0.04425 TF:M11736 Factor: TLX; motif: NNAAGTCAN 1378 54
0.04587 TF:M11899_1 Factor: Oct-2; motif: NTGCATATGCAN; match class: 1 3418 112
0.04587 TF:M04609 Factor: AP-3; motif: TKGAAAKN 3345 110
0.04599 TF:M08765_1 Factor: GATA-1; motif: NGATAAN; match class: 1 300 18
0.04599 TF:M07214_1 Factor: GATA3; motif: AGATAAGA; match class: 1 300 18
0.04599 TF:M03216_1 Factor: GATA-6; motif: AGATAAN; match class: 1 300 18
0.04599 TF:M00789_1 Factor: GATA; motif: WGATARN; match class: 1 300 18
0.04599 TF:M01292_1 Factor: HOXA13; motif: ATAAMA; match class: 1 6372 189
0.04599 TF:M11286 Factor: Fra-1; motif: NATGAWTCAYN 2416 84
0.04599 TF:M01230_1 Factor: ZNF333; motif: ATAAT; match class: 1 8866 250
0.04725 TF:M01878_1 Factor: GATA-3; motif: AGATAA; match class: 1 3211 106
0.04923 TF:M10535_1 Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 1969 71
0.04956 TF:M11929_1 Factor: POU3F1; motif: NTAATKWATGCNN; match class: 1 1395 54

G4 Enrichment

Up Regulated Genes

p_value term_id term_name term_size intersection_size
0.00000 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 35 12
0.00000 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 164 14
0.00008 GO:0034329 cell junction assembly 333 16
0.00010 GO:0007416 synapse assembly 117 10
0.00074 GO:0007155 cell adhesion 1050 27
0.00074 GO:0022610 biological adhesion 1056 27
0.00075 GO:0098609 cell-cell adhesion 634 20
0.00510 GO:0034330 cell junction organization 492 16
0.03344 GO:0050808 synapse organization 248 10
0.03474 GO:0007268 chemical synaptic transmission 473 14
0.03474 GO:0098916 anterograde trans-synaptic signaling 473 14
0.03551 GO:0099537 trans-synaptic signaling 478 14
0.04041 GO:0018916 nitrobenzene metabolic process 3 2
0.04041 GO:0051410 detoxification of nitrogen compound 3 2
0.04041 GO:0070458 cellular detoxification of nitrogen compound 3 2
0.04041 GO:0099536 synaptic signaling 497 14

Down Regulated Genes

p_value term_id term_name term_size intersection_size
0.03395 GO:0072359 circulatory system development 745 49
0.03788 GO:0051241 negative regulation of multicellular organismal process 791 49
0.03788 GO:1902869 regulation of amacrine cell differentiation 3 3
0.03788 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 3 3
0.03788 GO:0032501 multicellular organismal process 5090 217
0.04034 GO:0051093 negative regulation of developmental process 587 39
0.00188 GO:0031226 intrinsic component of plasma membrane 1419 80
0.00194 GO:0005887 integral component of plasma membrane 1353 76
0.02207 GO:0071944 cell periphery 4545 193
0.03809 GO:0001067 transcription regulatory region nucleic acid binding 1293 65
0.03809 GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 1031 55
0.03809 GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 1206 63
0.03809 GO:0003700 DNA-binding transcription factor activity 1231 65
0.03809 GO:0000976 transcription cis-regulatory region binding 1292 65
0.03809 GO:0015318 inorganic molecular entity transmembrane transporter activity 577 36
0.03809 GO:0022834 ligand-gated channel activity 118 12
0.03809 GO:0022836 gated channel activity 251 20
0.03809 GO:0022848 acetylcholine-gated cation-selective channel activity 13 4
0.03809 GO:0022857 transmembrane transporter activity 836 46
0.03809 GO:0022890 inorganic cation transmembrane transporter activity 474 32
0.03809 GO:0008324 cation transmembrane transporter activity 517 33
0.03809 GO:0008009 chemokine activity 42 7
0.03809 GO:0005261 cation channel activity 270 21
0.03809 GO:0005216 ion channel activity 347 24
0.03809 GO:0046873 metal ion transmembrane transporter activity 359 25
0.03809 GO:0015276 ligand-gated ion channel activity 118 12
0.03809 GO:0099094 ligand-gated cation channel activity 97 11
0.03809 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 1193 64
0.03809 GO:0000987 cis-regulatory region sequence-specific DNA binding 1045 55
0.03809 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 10 4
0.03824 GO:0015075 ion transmembrane transporter activity 677 39
0.04234 GO:0038102 activin receptor antagonist activity 2 2
0.04234 GO:0150100 RNA binding involved in posttranscriptional gene silencing 143 13
0.04234 GO:1903231 mRNA binding involved in posttranscriptional gene silencing 143 13
0.04234 GO:0004917 interleukin-7 receptor activity 2 2
0.04543 GO:0005231 excitatory extracellular ligand-gated ion channel activity 25 5
0.04543 GO:0005215 transporter activity 927 49
0.04954 GO:0022803 passive transmembrane transporter activity 387 25
0.04954 GO:1990837 sequence-specific double-stranded DNA binding 1351 66
0.04954 GO:0015267 channel activity 387 25
0.00431 MIRNA:hsa-miR-335-5p hsa-miR-335-5p 2166 112
0.00084 TF:M10088 Factor: TBP; motif: MTATAAAARS 3740 178
0.00084 TF:M01010_1 Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 2423 127
0.00196 TF:M02087_1 Factor: CDX-2; motif: TTTATN; match class: 1 3834 179
0.00943 TF:M01654_1 Factor: DRI1; motif: AATTAA; match class: 1 4449 197
0.00943 TF:M03546_1 Factor: Dlx-5; motif: AATTAN; match class: 1 4449 197
0.00943 TF:M12193 Factor: GATA-3; motif: AGATAAGATCT 4849 211
0.00943 TF:M04073 Factor: POU2F2; motif: NWTRMATATKCAWN 3151 148
0.01044 TF:M07204_1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 740 48
0.01044 TF:M01010 Factor: HMGIY; motif: NNKKNAWTTTNYTNN 6335 263
0.01088 TF:M02087 Factor: CDX-2; motif: TTTATN 7660 308
0.01263 TF:M04360_1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 796 50
0.01263 TF:M00252 Factor: TATA; motif: STATAAAWRNNNNNN 3546 161
0.01593 TF:M04557 Factor: SRY; motif: TCAATAMCATTGA 7715 308
0.01593 TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 3517 159
0.01682 TF:M02097_1 Factor: LHX3; motif: ATTAAW; match class: 1 5026 214
0.01740 TF:M02112_1 Factor: OC-2; motif: TCAATA; match class: 1 1832 93
0.01740 TF:M01694 Factor: YY2; motif: CCATTWN 1909 96
0.01740 TF:M04555_1 Factor: SRY; motif: AACAATANCATTGTT; match class: 1 2638 125
0.01974 TF:M02112 Factor: OC-2; motif: TCAATA 5787 240
0.02381 TF:M10853 Factor: Cdx-1; motif: NGCMATAAAAC 1154 64
0.02671 TF:M11585_1 Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 1044 59
0.02729 TF:M01124_1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1377 73
0.03059 TF:M03581 Factor: TBP; motif: NGNNTATAAAA 5412 225
0.03082 TF:M04235 Factor: FOXC2; motif: NGTMAATATTKACN 359 27
0.03290 TF:M07270_1 Factor: TEF-3; motif: GNTATTTTT; match class: 1 3445 153
0.03290 TF:M00407 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN 1060 59
0.03480 TF:M03559_1 Factor: Pit-1; motif: NNWWATTCAT; match class: 1 1042 58
0.03480 TF:M01878_1 Factor: GATA-3; motif: AGATAA; match class: 1 3211 144
0.04702 TF:M12041_1 Factor: TEF-1; motif: CRCATWCCN; match class: 1 519 34
0.04702 TF:M04073_1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1865 91
0.04702 TF:M03581_1 Factor: TBP; motif: NGNNTATAAAA; match class: 1 1517 77
0.04702 TF:M00026 Factor: RSRFC4; motif: RNKCTATTTWTAGMWN 815 47
0.04702 TF:M00102 Factor: CDP; motif: NWNATCGATTANYNN 3127 139
0.04702 TF:M07214_1 Factor: GATA3; motif: AGATAAGA; match class: 1 300 23
0.04702 TF:M10535_1 Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 1969 95
0.04702 TF:M00789_1 Factor: GATA; motif: WGATARN; match class: 1 300 23
0.04702 TF:M07205 Factor: CEBPA; motif: ATTGCAYAAYN 1965 95
0.04702 TF:M03216_1 Factor: GATA-6; motif: AGATAAN; match class: 1 300 23
0.04702 TF:M08918_1 Factor: GATA-3; motif: WGATAASN; match class: 1 505 33
0.04702 TF:M11585 Factor: FOXJ2; motif: NNTGTTGTAAAYAN 4231 180
0.04702 TF:M03997_1 Factor: GATA3; motif: NGATAANN; match class: 1 505 33
0.04702 TF:M08765_1 Factor: GATA-1; motif: NGATAAN; match class: 1 300 23
0.04981 TF:M07364_1 Factor: NF-1; motif: TTGGCNN; match class: 1 552 35
0.04981 TF:M00148_1 Factor: SRY; motif: AAACWAM; match class: 1 3353 147
0.04981 TF:M02909_1 Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 707 42
0.04981 TF:M04557_1 Factor: SRY; motif: TCAATAMCATTGA; match class: 1 3784 163
0.04992 TF:M00133_1 Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 1008 55
0.04992 TF:M01292_1 Factor: HOXA13; motif: ATAAMA; match class: 1 6372 255
0.04992 TF:M01124 Factor: Oct-4; motif: ATTGWSWTGCWAAWN 4669 195

SHH Enrichment

Up Regulated Genes

p_value term_id term_name term_size intersection_size
0.00000 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 35 13
0.00000 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 164 19
0.00106 GO:0034329 cell junction assembly 333 23
0.00126 GO:0007416 synapse assembly 117 13
0.00162 GO:0034330 cell junction organization 492 28
0.00162 GO:0032501 multicellular organismal process 5090 149
0.00347 GO:0051241 negative regulation of multicellular organismal process 791 37
0.00500 GO:0030336 negative regulation of cell migration 256 18
0.00708 GO:0040013 negative regulation of locomotion 291 19
0.00708 GO:2000146 negative regulation of cell motility 267 18
0.00816 GO:0051271 negative regulation of cellular component movement 273 18
0.00816 GO:0050808 synapse organization 248 17
0.00860 GO:0007155 cell adhesion 1050 43
0.00913 GO:0022610 biological adhesion 1056 43
0.00975 GO:0060073 micturition 4 3
0.00975 GO:0098609 cell-cell adhesion 634 30
0.01374 GO:0072359 circulatory system development 745 33
0.01722 GO:0007268 chemical synaptic transmission 473 24
0.01722 GO:0098916 anterograde trans-synaptic signaling 473 24
0.01913 GO:0032502 developmental process 4171 120
0.01913 GO:0099537 trans-synaptic signaling 478 24
0.01922 GO:0014912 negative regulation of smooth muscle cell migration 23 5
0.02424 GO:0007275 multicellular organism development 3397 101
0.02495 GO:0048856 anatomical structure development 3824 111
0.02780 GO:0099536 synaptic signaling 497 24
0.04361 GO:0120163 negative regulation of cold-induced thermogenesis 43 6
0.00198 GO:0071944 cell periphery 4545 135
0.00770 GO:0016342 catenin complex 32 6
0.00770 GO:0031226 intrinsic component of plasma membrane 1419 53
0.01386 GO:0005886 plasma membrane 4147 119
0.01493 GO:0005887 integral component of plasma membrane 1353 49
0.02392 GO:0048179 activin receptor complex 7 3
0.01051 REAC:R-HSA-9031628 NGF-stimulated transcription 38 7
0.01510 REAC:R-HSA-1433617 Regulation of signaling by NODAL 10 4
0.03597 REAC:R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 6 3
0.03597 REAC:R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 55 7
0.03608 REAC:R-HSA-166520 Signaling by NTRKs 119 10
0.03973 REAC:R-HSA-187037 Signaling by NTRK1 (TRKA) 101 9

Down Regulated Genes

p_value term_id term_name term_size intersection_size
0.02914 GO:1902869 regulation of amacrine cell differentiation 3 3
0.02914 GO:0035881 amacrine cell differentiation 8 4
0.02384 GO:0008009 chemokine activity 42 7
0.04176 GO:0038102 activin receptor antagonist activity 2 2
0.04176 GO:0000976 transcription cis-regulatory region binding 1292 47
0.04176 GO:0003700 DNA-binding transcription factor activity 1231 46
0.04176 GO:0001067 transcription regulatory region nucleic acid binding 1293 47
0.04176 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 1193 44
0.04176 GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 1206 45
0.04176 GO:0004917 interleukin-7 receptor activity 2 2
0.04176 GO:0042379 chemokine receptor binding 54 7
0.04738 GO:1990837 sequence-specific double-stranded DNA binding 1351 48
0.03520 KEGG:04061 Viral protein interaction with cytokine and cytokine receptor 89 9
0.01297 REAC:R-HSA-500792 GPCR ligand binding 419 23
0.01297 REAC:R-HSA-388396 GPCR downstream signalling 978 42
0.01297 REAC:R-HSA-372790 Signaling by GPCR 1038 43
0.01745 REAC:R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 296 18
0.02035 REAC:R-HSA-380108 Chemokine receptors bind chemokines 53 7
0.02238 REAC:R-HSA-418594 G alpha (i) signalling events 368 20
0.03188 REAC:R-HSA-6783783 Interleukin-10 signaling 43 6
0.00000 TF:M04073 Factor: POU2F2; motif: NWTRMATATKCAWN 3151 120
0.00002 TF:M02097_1 Factor: LHX3; motif: ATTAAW; match class: 1 5026 162
0.00002 TF:M01230_1 Factor: ZNF333; motif: ATAAT; match class: 1 8866 247
0.00004 TF:M01124 Factor: Oct-4; motif: ATTGWSWTGCWAAWN 4669 151
0.00005 TF:M08836 Factor: OCT-2; motif: ATGMATATGCWAAT 2812 103
0.00005 TF:M01124_1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1377 62
0.00005 TF:M03546_1 Factor: Dlx-5; motif: AATTAN; match class: 1 4449 144
0.00005 TF:M01654_1 Factor: DRI1; motif: AATTAA; match class: 1 4449 144
0.00005 TF:M01010_1 Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 2423 92
0.00005 TF:M02087 Factor: CDX-2; motif: TTTATN 7660 218
0.00006 TF:M12193 Factor: GATA-3; motif: AGATAAGATCT 4849 153
0.00006 TF:M01010 Factor: HMGIY; motif: NNKKNAWTTTNYTNN 6335 188
0.00006 TF:M02087_1 Factor: CDX-2; motif: TTTATN; match class: 1 3834 128
0.00006 TF:M04556 Factor: SRY; motif: AACAATNNNCATTGTT 6044 181
0.00007 TF:M04073_1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1865 75
0.00009 TF:M02112 Factor: OC-2; motif: TCAATA 5787 174
0.00010 TF:M11894 Factor: Oct-2; motif: NNNATTATGCAW 2844 101
0.00010 TF:M04556_1 Factor: SRY; motif: AACAATNNNCATTGTT; match class: 1 4704 148
0.00011 TF:M10088 Factor: TBP; motif: MTATAAAARS 3740 124
0.00015 TF:M03581 Factor: TBP; motif: NGNNTATAAAA 5412 164
0.00015 TF:M04557 Factor: SRY; motif: TCAATAMCATTGA 7715 216
0.00020 TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 3517 117
0.00020 TF:M00102 Factor: CDP; motif: NWNATCGATTANYNN 3127 107
0.00021 TF:M07270_1 Factor: TEF-3; motif: GNTATTTTT; match class: 1 3445 115
0.00026 TF:M00252 Factor: TATA; motif: STATAAAWRNNNNNN 3546 117
0.00026 TF:M04557_1 Factor: SRY; motif: TCAATAMCATTGA; match class: 1 3784 123
0.00026 TF:M04360_1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 796 40
0.00033 TF:M02112_1 Factor: OC-2; motif: TCAATA; match class: 1 1832 71
0.00035 TF:M10801 Factor: HOXA10; motif: NRTCGTAAANN 2987 102
0.00035 TF:M01694 Factor: YY2; motif: CCATTWN 1909 73
0.00036 TF:M08520_1 Factor: CDP:SRF; motif: NCCWTAYAAGGTMNKRATCRATN; match class: 1 2461 88
0.00036 TF:M08201 Factor: CDP:HOXA13; motif: ATCGATYAYSYCRTAAA 6121 178
0.00037 TF:M10797 Factor: HOXA10; motif: RGTCGTAAAAN 4269 134
0.00037 TF:M00346 Factor: GATA-1; motif: NCWGATAACA 3388 112
0.00043 TF:M00133_1 Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 1008 46
0.00044 TF:M04555 Factor: SRY; motif: AACAATANCATTGTT 5414 161
0.00050 TF:M07270 Factor: TEF-3; motif: GNTATTTTT 7818 215
0.00052 TF:M03813_1 Factor: BRN1; motif: HAATGCN; match class: 1 5433 161
0.00056 TF:M09646 Factor: Oct3; motif: NYWTTSWTATGCAAAT 4352 135
0.00060 TF:M00148_1 Factor: SRY; motif: AAACWAM; match class: 1 3353 110
0.00068 TF:M01292_1 Factor: HOXA13; motif: ATAAMA; match class: 1 6372 182
0.00072 TF:M07205 Factor: CEBPA; motif: ATTGCAYAAYN 1965 73
0.00075 TF:M10535_1 Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 1969 73
0.00076 TF:M00805_1 Factor: TCF-7; motif: TCAAAG; match class: 1 4222 131
0.00076 TF:M03858_1 Factor: TCF-3; motif: CTTTGA; match class: 1 4222 131
0.00112 TF:M01878_1 Factor: GATA-3; motif: AGATAA; match class: 1 3211 105
0.00112 TF:M00802 Factor: Pit-1; motif: NMTTCATAAWTATWNMNA 3649 116
0.00112 TF:M00423 Factor: FOXJ2; motif: AYMATAATATTTKN 5302 156
0.00131 TF:M00136 Factor: Oct-1; motif: NNGAATATKCANNNN 3225 105
0.00132 TF:M04609 Factor: AP-3; motif: TKGAAAKN 3345 108
0.00133 TF:M03564_1 Factor: SATB1; motif: NTTTAT; match class: 1 9202 242
0.00140 TF:M01654 Factor: DRI1; motif: AATTAA 8362 224
0.00140 TF:M03546 Factor: Dlx-5; motif: AATTAN 8362 224
0.00142 TF:M00026 Factor: RSRFC4; motif: RNKCTATTTWTAGMWN 815 38
0.00144 TF:M11899 Factor: Oct-2; motif: NTGCATATGCAN 4247 130
0.00151 TF:M11585_1 Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 1044 45
0.00190 TF:M04635 Factor: TEF-5; motif: AAAAATAT 2449 84
0.00193 TF:M01723_1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 385 23
0.00202 TF:M01149 Factor: DMRT4; motif: AATGTADCAAWTT 1398 55
0.00207 TF:M00407 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN 1060 45
0.00260 TF:M03849_1 Factor: Sox-4; motif: AACAAA; match class: 1 6977 192
0.00260 TF:M07230 Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG 2861 94
0.00260 TF:M04335 Factor: HMX3; motif: NNCAMTTAANN 4183 127
0.00263 TF:M09597 Factor: C/EBPbeta; motif: NATTGCRYAAYN 2326 80
0.00274 TF:M03555_1 Factor: NFATc2; motif: GGAAAA; match class: 1 8590 227
0.00274 TF:M01886_1 Factor: NFATc3; motif: GGAAAA; match class: 1 8590 227
0.00274 TF:M01281_1 Factor: NFATc2; motif: GGAAAA; match class: 1 8590 227
0.00282 TF:M00347 Factor: GATA-1; motif: MNAGATAANR 3465 109
0.00329 TF:M00351 Factor: GATA-3; motif: ANAGATMWWA 2046 72
0.00329 TF:M08792 Factor: MEL1; motif: GATAAGATAA 1789 65
0.00346 TF:M01255 Factor: ipf1; motif: RNWCATTAANWN 3048 98
0.00346 TF:M01292 Factor: HOXA13; motif: ATAAMA 10296 262
0.00351 TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 2165 75
0.00369 TF:M08201_1 Factor: CDP:HOXA13; motif: ATCGATYAYSYCRTAAA; match class: 1 2396 81
0.00392 TF:M02909_1 Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 707 33
0.00446 TF:M03559 Factor: Pit-1; motif: NNWWATTCAT 4039 122
0.00457 TF:M07476_1 Factor: Lhx8; motif: TGATTG; match class: 1 2337 79
0.00495 TF:M04300 Factor: Dlx-2; motif: NYAATTAN 4215 126
0.00516 TF:M08976_1 Factor: SRY; motif: AACAATNR; match class: 1 6181 172
0.00549 TF:M10799 Factor: HOXA10; motif: NRTCGTAAANN 4352 129
0.00549 TF:M11929_1 Factor: POU3F1; motif: NTAATKWATGCNN; match class: 1 1395 53
0.00564 TF:M11585 Factor: FOXJ2; motif: NNTGTTGTAAAYAN 4231 126
0.00574 TF:M01451 Factor: HOXB8; motif: NNNNGYAATTAATANW 1121 45
0.00574 TF:M11899_1 Factor: Oct-2; motif: NTGCATATGCAN; match class: 1 3418 106
0.00633 TF:M10092_1 Factor: TEF-1; motif: RCATTCCWGNNN; match class: 1 237 16
0.00633 TF:M07457 Factor: Hoxa9; motif: NTTAAWTAMA 3630 111
0.00638 TF:M07278 Factor: Dlx-3; motif: NTAATTNVN 2716 88
0.00698 TF:M02079_1 Factor: Isl2; motif: CTAATKR; match class: 1 897 38
0.00698 TF:M04075 Factor: POU2F3; motif: ATGMATATKCAW 1168 46
0.00733 TF:M03950 Factor: CDP; motif: ATCGATNNNNNATCRAT 3243 101
0.00770 TF:M08203_1 Factor: CDP:T-bet; motif: NTCACACNYYRATCRATM; match class: 1 1140 45
0.00770 TF:M03548_1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 772 34
0.00844 TF:M02026_1 Factor: MEF-2D; motif: WAAATAR; match class: 1 1864 65
0.00844 TF:M10701 Factor: HOXB5; motif: GTCATTAN 4572 133
0.00859 TF:M08836_1 Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 619 29
0.00896 TF:M02006_1 Factor: GATA-5; motif: TATCTN; match class: 1 2361 78
0.00912 TF:M04068 Factor: POU1F1; motif: NNNATGMATAWTTAATN 2673 86
0.00942 TF:M04442 Factor: UNCX; motif: NTAATNNAATTAN 1763 62
0.00942 TF:M04555_1 Factor: SRY; motif: AACAATANCATTGTT; match class: 1 2638 85
0.00950 TF:M12070 Factor: CIZ; motif: TTTTNNNNNNNNNNNNNAAAAA 1988 68
0.00953 TF:M01883_1 Factor: IRF-4; motif: GAAARTA; match class: 1 2297 76
0.00953 TF:M08918_1 Factor: GATA-3; motif: WGATAASN; match class: 1 505 25
0.00953 TF:M11507 Factor: CDP; motif: NTATTGATYR 2409 79
0.00953 TF:M03997_1 Factor: GATA3; motif: NGATAANN; match class: 1 505 25
0.00953 TF:M01324 Factor: BRN1; motif: NANNTATGCATAATNNA 3848 115
0.00953 TF:M12195 Factor: GATA-3; motif: MGATAASATCT 2956 93
0.00953 TF:M08772 Factor: HOXA6; motif: NYMATTAN 6055 167
0.00953 TF:M04235 Factor: FOXC2; motif: NGTMAATATTKACN 359 20
0.00953 TF:M10724 Factor: HOXD8; motif: GYMATTAN 2257 75
0.00953 TF:M01408 Factor: Brn-3c; motif: NNTTATTAATKANKNC 3768 113
0.00955 TF:M01723 Factor: SATB1; motif: AKWAWTAAHGRYMNWW 2454 80
0.00955 TF:M10031_1 Factor: ipf1; motif: TGATTGATK; match class: 1 2766 88
0.00955 TF:M12070_1 Factor: CIZ; motif: TTTTNNNNNNNNNNNNNAAAAA; match class: 1 1959 67
0.00992 TF:M02027_1 Factor: PARP; motif: TTTCYN; match class: 1 9298 238
0.00992 TF:M07213 Factor: GATA2; motif: NNNTTCTTATCTSN 2929 92
0.01058 TF:M02025_1 Factor: MEF-2C; motif: TATTTWT; match class: 1 5856 162
0.01066 TF:M09881 Factor: C/EBPbeta; motif: NRTTRYGCAATN 2082 70
0.01066 TF:M10858 Factor: En-2; motif: NTCRTTARN 7052 189
0.01072 TF:M03952 Factor: CDP; motif: TRATCRATAN 3339 102
0.01072 TF:M07450 Factor: HOXA9; motif: DTGATTTATKGY 3623 109
0.01119 TF:M00349 Factor: GATA-2; motif: ASAGATAANA 3143 97
0.01119 TF:M02097 Factor: LHX3; motif: ATTAAW 9128 234
0.01122 TF:M10864 Factor: EVX1; motif: NTCATTAN 4124 121
0.01122 TF:M03842 Factor: POU3F1; motif: RNYBCATTTGCATTWCAA 4041 119
0.01187 TF:M02026 Factor: MEF-2D; motif: WAAATAR 5876 162
0.01192 TF:M00423_1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 2095 70
0.01211 TF:M03549_1 Factor: GATA-4; motif: AGATAAN; match class: 1 739 32
0.01223 TF:M09624 Factor: GATA-6; motif: NNNAGATAAGAWAN 2444 79
0.01223 TF:M03559_1 Factor: Pit-1; motif: NNWWATTCAT; match class: 1 1042 41
0.01226 TF:M12041_1 Factor: TEF-1; motif: CRCATWCCN; match class: 1 519 25
0.01229 TF:M11000 Factor: LIM-1; motif: NYAATTAN 4514 130
0.01246 TF:M04360 Factor: HOXD11; motif: NNYMATAAAA 3768 112
0.01285 TF:M11908 Factor: POU3F2; motif: TAATKAGNNNNTAATKA 2843 89
0.01317 TF:M01883 Factor: IRF-4; motif: GAAARTA 6378 173
0.01317 TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 6466 175
0.01372 TF:M02909 Factor: Sox-4; motif: NNNNNAATTGTTNNNNN 3412 103
0.01372 TF:M01230 Factor: ZNF333; motif: ATAAT 11903 290
0.01416 TF:M10852 Factor: Cdx-1; motif: NGTCGTAAAWN 1626 57
0.01416 TF:M03581_1 Factor: TBP; motif: NGNNTATAAAA; match class: 1 1517 54
0.01416 TF:M03854_1 Factor: SRY; motif: TTGTTT; match class: 1 7013 187
0.01416 TF:M03823_1 Factor: FOXO1A; motif: AAACAA; match class: 1 7013 187
0.01430 TF:M11571 Factor: HNF-3alpha; motif: YTRWGTMAATATTTRCWYWN 3298 100
0.01445 TF:M01058 Factor: Gfi1b; motif: TAAATCACTGCW 1338 49
0.01453 TF:M07298_1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 189 13
0.01453 TF:M00102_1 Factor: CDP; motif: NWNATCGATTANYNN; match class: 1 687 30
0.01455 TF:M10036 Factor: Oct3; motif: CYWTTSWNATGCAAAT 3302 100
0.01482 TF:M02006 Factor: GATA-5; motif: TATCTN 7024 187
0.01482 TF:M08817 Factor: HOXD13; motif: WNNAATAAWAY 4334 125
0.01491 TF:M02115 Factor: Prx2; motif: TYAWAKTAA 2746 86
0.01491 TF:M01275_1 Factor: ipf1; motif: CATTAR; match class: 1 2628 83
0.01494 TF:M00802_1 Factor: Pit-1; motif: NMTTCATAAWTATWNMNA; match class: 1 855 35
0.01624 TF:M12333_1 Factor: ZBTB20; motif: NNAAYGTATRKN; match class: 1 298 17
0.01625 TF:M07457_1 Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 1277 47
0.01677 TF:M03216_1 Factor: GATA-6; motif: AGATAAN; match class: 1 300 17
0.01677 TF:M07214_1 Factor: GATA3; motif: AGATAAGA; match class: 1 300 17
0.01677 TF:M08765_1 Factor: GATA-1; motif: NGATAAN; match class: 1 300 17
0.01677 TF:M02086 Factor: Cdx-1; motif: TTTATK 11083 273
0.01677 TF:M00789_1 Factor: GATA; motif: WGATARN; match class: 1 300 17
0.01677 TF:M11910_1 Factor: POU3F2; motif: NTAATTTATGCRN; match class: 1 632 28
0.01703 TF:M10526 Factor: Blimp-1; motif: RRGNGAAAGNRANNN 1834 62
0.01775 TF:M04256 Factor: FOXO1; motif: GTAAACATGTTTAC 3006 92
0.01775 TF:M11894_1 Factor: Oct-2; motif: NNNATTATGCAW; match class: 1 478 23
0.01775 TF:M11929 Factor: POU3F1; motif: NTAATKWATGCNN 5083 142
0.01843 TF:M11513 Factor: DMRT5; motif: NNNNGWTACANT 1654 57
0.01883 TF:M11921 Factor: Brn-4; motif: NATTATGCAWGN 1042 40
0.01890 TF:M04715 Factor: Oct-2; motif: ATTTGCA 4921 138
0.01890 TF:M00432 Factor: TTF1; motif: ASTCAAGTRK 4120 119
0.01906 TF:M01275 Factor: ipf1; motif: CATTAR 6799 181
0.01916 TF:M09787 Factor: SOX13; motif: NNACAATGGNN 513 24
0.01943 TF:M04611_1 Factor: FOXM1; motif: NAGASTGATTA; match class: 1 2660 83
0.02014 TF:M04119 Factor: MGA; motif: GGTGTGAAWTTTCACACC 2 2
0.02014 TF:M04119_1 Factor: MGA; motif: GGTGTGAAWTTTCACACC; match class: 1 2 2
0.02023 TF:M10853 Factor: Cdx-1; motif: NGCMATAAAAC 1154 43
0.02023 TF:M11908_1 Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 979 38
0.02031 TF:M11584_1 Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 742 31
0.02038 TF:M04383 Factor: LBX2; motif: CTNRANSTAATTA 6148 166
0.02047 TF:M01324_1 Factor: BRN1; motif: NANNTATGCATAATNNA; match class: 1 1263 46
0.02069 TF:M01878 Factor: GATA-3; motif: AGATAA 7808 203
0.02069 TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 613 27
0.02109 TF:M08768 Factor: HOXA10; motif: RGTMGTAAAAN 338 18
0.02127 TF:M03842_1 Factor: POU3F1; motif: RNYBCATTTGCATTWCAA; match class: 1 949 37
0.02134 TF:M00464 Factor: POU3F2; motif: TTATGYTAAT 2634 82
0.02140 TF:M08773 Factor: HOXA7; motif: NYMATTAN 3521 104
0.02141 TF:M08928 Factor: FOSB:JUND; motif: NNTNACTNATN 4736 133
0.02141 TF:M08202_1 Factor: CDP:HOXB13; motif: SYMRTAAANATYGATY; match class: 1 553 25
0.02141 TF:M07254_1 Factor: Foxc1; motif: TTVYTTTNW; match class: 1 2015 66
0.02141 TF:M11905_1 Factor: POU3F2; motif: NTAATTTATGCGY; match class: 1 553 25
0.02141 TF:M03950_1 Factor: CDP; motif: ATCGATNNNNNATCRAT; match class: 1 1163 43
0.02141 TF:M10867 Factor: EVX2; motif: NTCRTTAN 585 26
0.02141 TF:M10726 Factor: HOXB8; motif: NYMATTAN 1787 60
0.02141 TF:M10712 Factor: HOXD4; motif: NYMATTAN 3199 96
0.02141 TF:M10713 Factor: HOXD4; motif: RTCRTTAN 2995 91
0.02147 TF:M10690_1 Factor: HOXA7; motif: GYMATTAN; match class: 1 4780 134
0.02149 TF:M09929_1 Factor: FOXK1; motif: TGTTTNCNNT; match class: 1 491 23
0.02152 TF:M04281 Factor: ALX4; motif: NTAATYNAATTAN 554 25
0.02259 TF:M02086_1 Factor: Cdx-1; motif: TTTATK; match class: 1 7466 195
0.02260 TF:M02025 Factor: MEF-2C; motif: TATTTWT 9834 246
0.02401 TF:M00463 Factor: POU3F2; motif: ATGMATWWATTCAT 2416 76
0.02401 TF:M12208 Factor: GATA-6; motif: WGATAACGATCW 3254 97
0.02401 TF:M07378 Factor: cdx; motif: NNTTTATNN 995 38
0.02401 TF:M11286 Factor: Fra-1; motif: NATGAWTCAYN 2416 76
0.02401 TF:M01125 Factor: Oct-4; motif: YWTTSTNATGCAAAT 1574 54
0.02461 TF:M08482_1 Factor: FOXO1A:HOXA10; motif: RWMAACANCRTWAA; match class: 1 529 24
0.02484 TF:M10816 Factor: HOXC11; motif: NGYMATWAANN 4001 115
0.02496 TF:M00672 Factor: TEF; motif: ATGTTWAYATAA 4548 128
0.02544 TF:M10717 Factor: HOXC4; motif: NTMATTAN 2819 86
0.02580 TF:M11604 Factor: LEF-1; motif: ASATCAAAG 2861 87
0.02580 TF:M09646_1 Factor: Oct3; motif: NYWTTSWTATGCAAAT; match class: 1 1107 41
0.02598 TF:M00980 Factor: TBP; motif: TTTATAN 2114 68
0.02598 TF:M10707_1 Factor: HoxA5; motif: RTCATTAN; match class: 1 291 16
0.02639 TF:M07315 Factor: C/EBPbeta; motif: NNTTKCNNMAN 2310 73
0.02646 TF:M01414_1 Factor: NKX25; motif: NNANCCACTTRAAWTT; match class: 1 2507 78
0.02691 TF:M00991 Factor: Cdx; motif: NAYNRHNARAKTHATAAA 2787 85
0.02726 TF:M08471_1 Factor: Fli-1:HOXB13; motif: NNCGGAARYNRTWAA; match class: 1 731 30
0.02746 TF:M12192 Factor: GATA-3; motif: AGATAACGATCW 3685 107
0.02746 TF:M10816_1 Factor: HOXC11; motif: NGYMATWAANN; match class: 1 799 32
0.02790 TF:M02265_1 Factor: NFATc2; motif: TTTTCCA; match class: 1 1552 53
0.02790 TF:M04288 Factor: BARHL2; motif: NNTAATTGNN 1404 49
0.02794 TF:M11286_1 Factor: Fra-1; motif: NATGAWTCAYN; match class: 1 1779 59
0.02794 TF:M03874 Factor: Hoxa9; motif: ATYAATDACATC 1893 62
0.02794 TF:M04610 Factor: CDP; motif: NNNNWGWYMAATR 3483 102
0.02794 TF:M03548 Factor: FOXL2; motif: TWAKACWAMTTT 3606 105
0.02802 TF:M08940_1 Factor: C-JUN:FRA-2; motif: NNRTGAGTCAYN; match class: 1 602 26
0.02817 TF:M10710 Factor: HOXD4; motif: RTCRTTAN 2636 81
0.02860 TF:M11696 Factor: MEF-2B1; motif: CCNWATWWRG 1744 58
0.02860 TF:M11600 Factor: TCF-1; motif: ASATCAAAG 4914 136
0.03015 TF:M07076 Factor: c-Jun:B-ATF; motif: RNWATGASTCA 2445 76
0.03032 TF:M01404_1 Factor: HOXD13; motif: NNNYYAATAAAANNNN; match class: 1 639 27
0.03047 TF:M07104 Factor: JunD; motif: NRTGASTCATN 2056 66
0.03047 TF:M04082 Factor: POU3F3; motif: WTNAATAWKNAW 2765 84
0.03057 TF:M10062 Factor: SNF2L; motif: NMARGAAGMATN 1903 62
0.03076 TF:M01393_1 Factor: Msx-2; motif: NNNGACYAATTAGYNNT; match class: 1 3089 92
0.03082 TF:M10739 Factor: HOXB2; motif: RTCATTAN 3009 90
0.03082 TF:M07476 Factor: Lhx8; motif: TGATTG 6985 183
0.03091 TF:M07412 Factor: C/EBPalpha; motif: ATTGCGYAAY 2649 81
0.03091 TF:M07080 Factor: C/EBPbeta; motif: KATTGCAYMAY 1527 52
0.03091 TF:M11566 Factor: HNF-3alpha; motif: NWRWGTMAAYAW 2729 83
0.03112 TF:M07298 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN 1491 51
0.03218 TF:M04384 Factor: LBX2; motif: NNYAATTANN 2814 85
0.03218 TF:M08801 Factor: C/EBPepsilon; motif: MTTDCNNMAB 677 28
0.03218 TF:M07254 Factor: Foxc1; motif: TTVYTTTNW 5931 159
0.03270 TF:M01884 Factor: IRF-7; motif: AAGWGAA 8452 215
0.03270 TF:M07058 Factor: POU2F1; motif: ATTTGCATN 2577 79
0.03270 TF:M04383_1 Factor: LBX2; motif: CTNRANSTAATTA; match class: 1 1874 61
0.03363 TF:M07599_1 Factor: beta-catenin; motif: CTTTGATN; match class: 1 1800 59
0.03387 TF:M10690 Factor: HOXA7; motif: GYMATTAN 8274 211
0.03387 TF:M10800 Factor: HOXA10; motif: NGYMATAAANN 2701 82
0.03389 TF:M10707 Factor: HoxA5; motif: RTCATTAN 2305 72
0.03405 TF:M09933_1 Factor: FOXP1; motif: TNTGTTTMY; match class: 1 486 22
0.03405 TF:M09725 Factor: DREF; motif: CTYYCWCTTCCY 5898 158
0.03438 TF:M07319_1 Factor: HFH2; motif: AAACAAAN; match class: 1 167 11
0.03460 TF:M04715_1 Factor: Oct-2; motif: ATTTGCA; match class: 1 1354 47
0.03460 TF:M10928 Factor: Prop-1; motif: TAATTNNRTTA 1391 48
0.03464 TF:M02085 Factor: Bcl-6; motif: NTTYCTAGRA 3850 110
0.03584 TF:M09888 Factor: Crx; motif: NAAGRGGATTARN 553 24
0.03584 TF:M01337_1 Factor: HOXA3; motif: NNNNRNTAATTARY; match class: 1 9261 232
0.03589 TF:M08202 Factor: CDP:HOXB13; motif: SYMRTAAANATYGATY 3114 92
0.03589 TF:M00454 Factor: MRF2; motif: AWSCACAATACNVA 521 23
0.03630 TF:M12194 Factor: GATA-3; motif: MGATAACGATCT 2592 79
0.03630 TF:M11611 Factor: LEF-1; motif: ASATCAAAG 2712 82
0.03687 TF:M01301 Factor: MEF-2A; motif: YTAAAAATARCY 963 36
0.03687 TF:M10802 Factor: HOXA10; motif: NGYMATAAANN 2754 83
0.03789 TF:M04433 Factor: PRRX2; motif: NYAATTAN 2438 75
0.03793 TF:M04317 Factor: EN1; motif: TAATTRSNYAATTA 2163 68
0.03926 TF:M11910 Factor: POU3F2; motif: NTAATTTATGCRN 3207 94
0.04103 TF:M10603 Factor: Dlx-7; motif: NTCRTTAN 6326 167
0.04103 TF:M00095 Factor: CDP; motif: CCAATAATCGAT 6547 172
0.04103 TF:M10612 Factor: Dlx-5; motif: NTCRTTAN 6326 167
0.04132 TF:M01425_1 Factor: HNF-1beta; motif: NNNNGTTAACTAGNNNT; match class: 1 1333 46
0.04146 TF:M11606 Factor: LEF-1; motif: ASATCAAAG 4678 129
0.04146 TF:M07079 Factor: Cdx-2; motif: NNGYMATAAAA 1445 49
0.04163 TF:M08817_1 Factor: HOXD13; motif: WNNAATAAWAY; match class: 1 1224 43
0.04256 TF:M04258 Factor: FOXO3; motif: GTAAACATGTTTAC 2215 69
0.04256 TF:M00532 Factor: RP58; motif: NNAACATCTGGA 313 16
0.04269 TF:M01420 Factor: Ncx; motif: NAATNAATTAATAANWW 4386 122
0.04269 TF:M08473 Factor: FOXJ2:HOXB13; motif: TTTTATNDGNMAACA 1263 44
0.04361 TF:M04078 Factor: POU3F2; motif: NWTGCATAAWTTA 3018 89
0.04363 TF:M04317_1 Factor: EN1; motif: TAATTRSNYAATTA; match class: 1 698 28
0.04429 TF:M10535 Factor: znf136; motif: CAAGAATWCTATAYCCAG 6385 168
0.04441 TF:M08772_1 Factor: HOXA6; motif: NYMATTAN; match class: 1 2025 64
0.04447 TF:M01817_1 Factor: TEF-1; motif: GWGGAATGT; match class: 1 345 17
0.04449 TF:M07257 Factor: HOXA10; motif: TTATNNYWN 2900 86
0.04602 TF:M10924_1 Factor: Gscl; motif: NTAATCCN; match class: 1 1233 43
0.04684 TF:M08520 Factor: CDP:SRF; motif: NCCWTAYAAGGTMNKRATCRATN 7378 190
0.04688 TF:M00116 Factor: C/EBPalpha; motif: NNATTRCNNAANNN 2624 79
0.04927 TF:M10704 Factor: HoxA5; motif: RTCATTAN 4195 117

WNT Enrichment

Up Regulated Genes

p_value term_id term_name term_size intersection_size
0.04475 CORUM:5375 EGR-EP300 complex 2 1
0.04475 CORUM:2886 Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial 2 1
0.04475 CORUM:3111 ITGA9-ITGB1-SPP1 complex 3 1
0.04475 CORUM:3112 ITGA5-ITGB1-SPP1 complex 3 1
0.04475 CORUM:3335 NIAP homotetramer complex 1 1
0.04475 CORUM:6078 HSPA2-ACR-PDIA6 complex 3 1
0.04475 CORUM:6616 CADM1-4.1B-MPP3 complex 2 1
0.04475 CORUM:6230 ULK2-ATG13-RB1CC1 complex 3 1
0.04475 CORUM:6235 c-Fos-c-Jun-SAF-1 complex 3 1
0.04475 CORUM:6396 DNJC3-DNAJB1-HSPA8 complex 3 1
0.04475 CORUM:6527 FLRT3-LPHN3-UNC5B complex 2 1
0.04475 CORUM:2885 ITGAV-ITGB1-SPP1 complex 3 1
0.04475 CORUM:6736 PRAME-Cullin2 ubiquitin ligase complex 2 1
0.04475 CORUM:6079 BAG6-HSPA2 complex 2 1
0.04475 CORUM:2786 BRCA1 A complex 3 1
0.04475 CORUM:7000 PLOD2-FKBP10 complex 2 1
0.04475 CORUM:2694 ERG-JUN-FOS DNA-protein complex 3 1
0.04475 CORUM:790 DDB complex 2 1
0.04475 CORUM:1123 WNK1-SPAK complex 2 1
0.04475 CORUM:2242 TGM2-HD-CALM1 complex 2 1
0.04475 CORUM:2243 TGM2-HD complex 2 1
0.04475 CORUM:2347 ITGAV-ITGB5-SPP1 complex 3 1
0.04475 CORUM:2695 ETS2-FOS-JUN complex 3 1
0.04475 CORUM:2358 ITGAV-ITGB3-SPP1 complex 3 1
0.04475 CORUM:2352 ITGAV-ITGB6-SPP1 complex 3 1
0.04475 CORUM:2375 FN1-TGM2 complex 2 1
0.04475 CORUM:6738 PRAME-ElonginBC ubiquitin ligase 2 1
0.04475 CORUM:2693 NFAT-JUN-FOS DNA-protein complex 3 1
0.04475 CORUM:2373 ITGAV-ITGB3-SPP1 complex 3 1
0.04788 CORUM:2376 ITGA2B-ITGB3-FN1-TGM2 complex 4 1
0.04788 CORUM:2383 ITGA5-ITGB1-FN1-TGM2 complex 4 1
0.04788 CORUM:6255 MICOS complex 4 1
0.04788 CORUM:6337 Amot-cadherin-11-beta-catenin-p120 complex 4 1
0.04788 CORUM:1162 Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) 4 1
0.04788 CORUM:2787 BRCA1 C complex 4 1
0.04788 CORUM:2692 SMAD3-SMAD4-cJun-cFos complex 4 1
0.00000 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 35 11
0.00001 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 164 12
0.00002 GO:0007416 synapse assembly 117 10
0.00004 GO:0034329 cell junction assembly 333 15
0.00007 GO:0007155 cell adhesion 1050 26
0.00007 GO:0022610 biological adhesion 1056 26
0.00020 GO:0098609 cell-cell adhesion 634 19
0.00245 GO:0034330 cell junction organization 492 15
0.00752 GO:0050808 synapse organization 248 10
0.02894 GO:0010633 negative regulation of epithelial cell migration 97 6
0.01871 MIRNA:hsa-miR-155-5p hsa-miR-155-5p 791 19

Down Regulated Genes

p_value term_id term_name term_size intersection_size
0.00154 GO:0005887 integral component of plasma membrane 1353 79
0.00154 GO:0031226 intrinsic component of plasma membrane 1419 82
0.01347 GO:0071944 cell periphery 4545 202
0.00741 MIRNA:hsa-miR-335-5p hsa-miR-335-5p 2166 115
0.00016 TF:M01010_1 Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 2423 135
0.00112 TF:M10088 Factor: TBP; motif: MTATAAAARS 3740 182
0.00112 TF:M02087_1 Factor: CDX-2; motif: TTTATN; match class: 1 3834 186
0.00112 TF:M03546_1 Factor: Dlx-5; motif: AATTAN; match class: 1 4449 209
0.00112 TF:M01654_1 Factor: DRI1; motif: AATTAA; match class: 1 4449 209
0.00112 TF:M01010 Factor: HMGIY; motif: NNKKNAWTTTNYTNN 6335 281
0.00112 TF:M12193 Factor: GATA-3; motif: AGATAAGATCT 4849 226
0.00230 TF:M02097_1 Factor: LHX3; motif: ATTAAW; match class: 1 5026 229
0.00282 TF:M04360_1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 796 54
0.00414 TF:M02087 Factor: CDX-2; motif: TTTATN 7660 323
0.00471 TF:M04073 Factor: POU2F2; motif: NWTRMATATKCAWN 3151 154
0.00539 TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 3517 168
0.00971 TF:M04557 Factor: SRY; motif: TCAATAMCATTGA 7715 322
0.00971 TF:M01878_1 Factor: GATA-3; motif: AGATAA; match class: 1 3211 154
0.00971 TF:M01124_1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1377 78
0.00971 TF:M04555_1 Factor: SRY; motif: AACAATANCATTGTT; match class: 1 2638 131
0.00975 TF:M03581_1 Factor: TBP; motif: NGNNTATAAAA; match class: 1 1517 84
0.01096 TF:M01230_1 Factor: ZNF333; motif: ATAAT; match class: 1 8866 361
0.01126 TF:M02112_1 Factor: OC-2; motif: TCAATA; match class: 1 1832 97
0.01210 TF:M01694 Factor: YY2; motif: CCATTWN 1909 100
0.01285 TF:M10853 Factor: Cdx-1; motif: NGCMATAAAAC 1154 67
0.01285 TF:M07204_1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 740 48
0.01285 TF:M11585_1 Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 1044 62
0.01285 TF:M03559_1 Factor: Pit-1; motif: NNWWATTCAT; match class: 1 1042 62
0.01324 TF:M12041_1 Factor: TEF-1; motif: CRCATWCCN; match class: 1 519 37
0.01438 TF:M07270_1 Factor: TEF-3; motif: GNTATTTTT; match class: 1 3445 161
0.01629 TF:M00148_1 Factor: SRY; motif: AAACWAM; match class: 1 3353 157
0.01751 TF:M00252 Factor: TATA; motif: STATAAAWRNNNNNN 3546 164
0.01751 TF:M00346 Factor: GATA-1; motif: NCWGATAACA 3388 158
0.01751 TF:M01292_1 Factor: HOXA13; motif: ATAAMA; match class: 1 6372 270
0.01751 TF:M10535_1 Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 1969 101
0.02051 TF:M02112 Factor: OC-2; motif: TCAATA 5787 248
0.02052 TF:M08836_1 Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 619 41
0.02256 TF:M12195 Factor: GATA-3; motif: MGATAASATCT 2956 140
0.02462 TF:M04557_1 Factor: SRY; motif: TCAATAMCATTGA; match class: 1 3784 172
0.02670 TF:M03581 Factor: TBP; motif: NGNNTATAAAA 5412 233
0.02670 TF:M01883_1 Factor: IRF-4; motif: GAAARTA; match class: 1 2297 113
0.02797 TF:M11899 Factor: Oct-2; motif: NTGCATATGCAN 4247 189
0.02797 TF:M04073_1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1865 95
0.02797 TF:M11908_1 Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 979 57
0.02861 TF:M07457_1 Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 1277 70
0.02914 TF:M10801 Factor: HOXA10; motif: NRTCGTAAANN 2987 140
0.02914 TF:M11585 Factor: FOXJ2; motif: NNTGTTGTAAAYAN 4231 188
0.02914 TF:M04609 Factor: AP-3; motif: TKGAAAKN 3345 154
0.03151 TF:M11908 Factor: POU3F2; motif: TAATKAGNNNNTAATKA 2843 134
0.03205 TF:M02909_1 Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 707 44
0.03205 TF:M04235 Factor: FOXC2; motif: NGTMAATATTKACN 359 27
0.03205 TF:M04068 Factor: POU1F1; motif: NNNATGMATAWTTAATN 2673 127
0.03205 TF:M00026 Factor: RSRFC4; motif: RNKCTATTTWTAGMWN 815 49
0.03752 TF:M07230 Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG 2861 134
0.03773 TF:M08836 Factor: OCT-2; motif: ATGMATATGCWAAT 2812 132
0.03882 TF:M04556 Factor: SRY; motif: AACAATNNNCATTGTT 6044 254
0.03882 TF:M00423_1 Factor: FOXJ2; motif: AYMATAATATTTKN; match class: 1 2095 103
0.03882 TF:M10707_1 Factor: HoxA5; motif: RTCATTAN; match class: 1 291 23
0.03882 TF:M03549_1 Factor: GATA-4; motif: AGATAAN; match class: 1 739 45
0.03882 TF:M01124 Factor: Oct-4; motif: ATTGWSWTGCWAAWN 4669 203
0.03894 TF:M00102 Factor: CDP; motif: NWNATCGATTANYNN 3127 144
0.03960 TF:M00133_1 Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 1008 57
0.04018 TF:M02079_1 Factor: Isl2; motif: CTAATKR; match class: 1 897 52
0.04069 TF:M03813_1 Factor: BRN1; motif: HAATGCN; match class: 1 5433 231
0.04069 TF:M10701 Factor: HOXB5; motif: GTCATTAN 4572 199
0.04219 TF:M00423 Factor: FOXJ2; motif: AYMATAATATTTKN 5302 226
0.04270 TF:M04555 Factor: SRY; motif: AACAATANCATTGTT 5414 230
0.04270 TF:M00407 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN 1060 59
0.04408 TF:M01255 Factor: ipf1; motif: RNWCATTAANWN 3048 140
0.04408 TF:M10858 Factor: En-2; motif: NTCRTTARN 7052 289
0.04408 TF:M00789_1 Factor: GATA; motif: WGATARN; match class: 1 300 23
0.04408 TF:M03216_1 Factor: GATA-6; motif: AGATAAN; match class: 1 300 23
0.04408 TF:M07214_1 Factor: GATA3; motif: AGATAAGA; match class: 1 300 23
0.04408 TF:M00351 Factor: GATA-3; motif: ANAGATMWWA 2046 100
0.04408 TF:M08765_1 Factor: GATA-1; motif: NGATAAN; match class: 1 300 23
0.04408 TF:M07298_1 Factor: Msx-1; motif: AHAWWTSMYYCAATTAN; match class: 1 189 17
0.04408 TF:M00347 Factor: GATA-1; motif: MNAGATAANR 3465 156
0.04408 TF:M03548_1 Factor: FOXL2; motif: TWAKACWAMTTT; match class: 1 772 46
0.04408 TF:M10701_1 Factor: HOXB5; motif: GTCATTAN; match class: 1 1068 59
0.04408 TF:M10713 Factor: HOXD4; motif: RTCRTTAN 2995 138
0.04874 TF:M07457 Factor: Hoxa9; motif: NTTAAWTAMA 3630 162

Transition Group Enrichment

Up Regulated Genes

p_value term_id term_name term_size intersection_size
0.00000 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 35 13
0.00000 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 164 17
0.00013 GO:0007155 cell adhesion 1050 35
0.00013 GO:0098609 cell-cell adhesion 634 26
0.00013 GO:0022610 biological adhesion 1056 35
0.00015 GO:0007416 synapse assembly 117 11
0.00015 GO:0034329 cell junction assembly 333 18
0.00696 GO:0120163 negative regulation of cold-induced thermogenesis 43 6
0.00733 GO:0034330 cell junction organization 492 19
0.01108 GO:0098916 anterograde trans-synaptic signaling 473 18
0.01108 GO:0007268 chemical synaptic transmission 473 18
0.01108 GO:0032501 multicellular organismal process 5090 93
0.01172 GO:0099537 trans-synaptic signaling 478 18
0.01794 GO:0099536 synaptic signaling 497 18
0.01945 GO:0050808 synapse organization 248 12
0.02462 GO:0030336 negative regulation of cell migration 256 12
0.03431 GO:2000146 negative regulation of cell motility 267 12
0.03483 GO:0014912 negative regulation of smooth muscle cell migration 23 4
0.03504 GO:0048856 anatomical structure development 3824 72
0.03581 GO:0051271 negative regulation of cellular component movement 273 12
0.04704 GO:0090136 epithelial cell-cell adhesion 11 3
0.04704 GO:0007275 multicellular organism development 3397 65
0.04824 GO:0014909 smooth muscle cell migration 49 5
0.04824 GO:0034332 adherens junction organization 48 5
0.04824 GO:0040013 negative regulation of locomotion 291 12
0.04824 GO:0090288 negative regulation of cellular response to growth factor stimulus 104 7
0.04824 GO:0007399 nervous system development 1503 35
0.04881 GO:0002689 negative regulation of leukocyte chemotaxis 12 3
0.04940 GO:0018916 nitrobenzene metabolic process 3 2
0.04940 GO:0051410 detoxification of nitrogen compound 3 2
0.04940 GO:0071603 endothelial cell-cell adhesion 3 2
0.04940 GO:0070458 cellular detoxification of nitrogen compound 3 2
0.01474 GO:0016342 catenin complex 32 5
0.01474 GO:0071944 cell periphery 4545 84

Down Regulated Genes

p_value term_id term_name term_size intersection_size
0.01719 GO:0031226 intrinsic component of plasma membrane 1419 70
0.02059 GO:0005887 integral component of plasma membrane 1353 66
0.01780 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 1193 61
0.01780 GO:0003700 DNA-binding transcription factor activity 1231 62
0.01780 GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 1206 61
0.01956 GO:0000976 transcription cis-regulatory region binding 1292 63
0.01956 GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 1031 53
0.01956 GO:0001067 transcription regulatory region nucleic acid binding 1293 63
0.02245 GO:0000987 cis-regulatory region sequence-specific DNA binding 1045 53
0.02521 GO:1990837 sequence-specific double-stranded DNA binding 1351 64
0.02521 GO:0008009 chemokine activity 42 7
0.03498 GO:1903231 mRNA binding involved in posttranscriptional gene silencing 143 13
0.03498 GO:0150100 RNA binding involved in posttranscriptional gene silencing 143 13
0.03747 GO:0003690 double-stranded DNA binding 1413 65
0.03798 GO:0043565 sequence-specific DNA binding 1418 65
0.04239 GO:0038102 activin receptor antagonist activity 2 2
0.04239 GO:0015276 ligand-gated ion channel activity 118 11
0.04239 GO:0022834 ligand-gated channel activity 118 11
0.04239 GO:0004917 interleukin-7 receptor activity 2 2
0.04239 GO:0015318 inorganic molecular entity transmembrane transporter activity 577 32
0.04239 GO:0022890 inorganic cation transmembrane transporter activity 474 28
0.04239 GO:0099094 ligand-gated cation channel activity 97 10
0.04906 GO:0042379 chemokine receptor binding 54 7
0.04906 GO:0008324 cation transmembrane transporter activity 517 29
0.01833 MIRNA:hsa-miR-335-5p hsa-miR-335-5p 2166 100
0.01530 REAC:R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 296 23
0.01530 REAC:R-HSA-500792 GPCR ligand binding 419 29
0.00027 TF:M01010_1 Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 2423 119
0.00053 TF:M10088 Factor: TBP; motif: MTATAAAARS 3740 163
0.00053 TF:M02087_1 Factor: CDX-2; motif: TTTATN; match class: 1 3834 166
0.00230 TF:M02087 Factor: CDX-2; motif: TTTATN 7660 285
0.00267 TF:M01010 Factor: HMGIY; motif: NNKKNAWTTTNYTNN 6335 243
0.00267 TF:M02097_1 Factor: LHX3; motif: ATTAAW; match class: 1 5026 201
0.00371 TF:M04073 Factor: POU2F2; motif: NWTRMATATKCAWN 3151 137
0.00702 TF:M10853 Factor: Cdx-1; motif: NGCMATAAAAC 1154 62
0.00702 TF:M03546_1 Factor: Dlx-5; motif: AATTAN; match class: 1 4449 178
0.00702 TF:M01654_1 Factor: DRI1; motif: AATTAA; match class: 1 4449 178
0.00702 TF:M12193 Factor: GATA-3; motif: AGATAAGATCT 4849 192
0.00702 TF:M01124_1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 1377 70
0.00702 TF:M04557_1 Factor: SRY; motif: TCAATAMCATTGA; match class: 1 3784 156
0.00702 TF:M04557 Factor: SRY; motif: TCAATAMCATTGA 7715 281
0.00702 TF:M01694 Factor: YY2; motif: CCATTWN 1909 90
0.00832 TF:M00252 Factor: TATA; motif: STATAAAWRNNNNNN 3546 147
0.00832 TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 3517 146
0.00897 TF:M12041_1 Factor: TEF-1; motif: CRCATWCCN; match class: 1 519 34
0.00897 TF:M04360_1 Factor: HOXD11; motif: NNYMATAAAA; match class: 1 796 46
0.00897 TF:M03581 Factor: TBP; motif: NGNNTATAAAA 5412 208
0.01291 TF:M07204_1 Factor: AR; motif: ARGAACANNNTGTNC; match class: 1 740 43
0.01291 TF:M00407 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN 1060 56
0.01636 TF:M04073_1 Factor: POU2F2; motif: NWTRMATATKCAWN; match class: 1 1865 86
0.01814 TF:M07270_1 Factor: TEF-3; motif: GNTATTTTT; match class: 1 3445 141
0.02169 TF:M10535_1 Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 1969 89
0.02169 TF:M08918_1 Factor: GATA-3; motif: WGATAASN; match class: 1 505 32
0.02169 TF:M03997_1 Factor: GATA3; motif: NGATAANN; match class: 1 505 32
0.02236 TF:M00026 Factor: RSRFC4; motif: RNKCTATTTWTAGMWN 815 45
0.02350 TF:M03581_1 Factor: TBP; motif: NGNNTATAAAA; match class: 1 1517 72
0.02350 TF:M11585_1 Factor: FOXJ2; motif: NNTGTTGTAAAYAN; match class: 1 1044 54
0.02509 TF:M02112 Factor: OC-2; motif: TCAATA 5787 216
0.02579 TF:M00351 Factor: GATA-3; motif: ANAGATMWWA 2046 91
0.02750 TF:M08765_1 Factor: GATA-1; motif: NGATAAN; match class: 1 300 22
0.02750 TF:M00789_1 Factor: GATA; motif: WGATARN; match class: 1 300 22
0.02750 TF:M10092_1 Factor: TEF-1; motif: RCATTCCWGNNN; match class: 1 237 19
0.02750 TF:M07214_1 Factor: GATA3; motif: AGATAAGA; match class: 1 300 22
0.02750 TF:M03216_1 Factor: GATA-6; motif: AGATAAN; match class: 1 300 22
0.03068 TF:M08836 Factor: OCT-2; motif: ATGMATATGCWAAT 2812 117
0.03068 TF:M04555_1 Factor: SRY; motif: AACAATANCATTGTT; match class: 1 2638 111
0.03068 TF:M07457_1 Factor: Hoxa9; motif: NTTAAWTAMA; match class: 1 1277 62
0.03454 TF:M01058 Factor: Gfi1b; motif: TAAATCACTGCW 1338 64
0.03454 TF:M00148_1 Factor: SRY; motif: AAACWAM; match class: 1 3353 135
0.03462 TF:M02079_1 Factor: Isl2; motif: CTAATKR; match class: 1 897 47
0.03561 TF:M02112_1 Factor: OC-2; motif: TCAATA; match class: 1 1832 82
0.03657 TF:M07278 Factor: Dlx-3; motif: NTAATTNVN 2716 113
0.03669 TF:M02026_1 Factor: MEF-2D; motif: WAAATAR; match class: 1 1864 83
0.03805 TF:M00133_1 Factor: Tst-1; motif: NNKGAATTAVAVTDN; match class: 1 1008 51
0.03805 TF:M00423 Factor: FOXJ2; motif: AYMATAATATTTKN 5302 198
0.03805 TF:M03858_1 Factor: TCF-3; motif: CTTTGA; match class: 1 4222 163
0.03805 TF:M11899 Factor: Oct-2; motif: NTGCATATGCAN 4247 164
0.03805 TF:M00805_1 Factor: TCF-7; motif: TCAAAG; match class: 1 4222 163
0.03805 TF:M02909_1 Factor: Sox-4; motif: NNNNNAATTGTTNNNNN; match class: 1 707 39
0.03805 TF:M00136 Factor: Oct-1; motif: NNGAATATKCANNNN 3225 130
0.03860 TF:M04235 Factor: FOXC2; motif: NGTMAATATTKACN 359 24
0.03982 TF:M08836_1 Factor: OCT-2; motif: ATGMATATGCWAAT; match class: 1 619 35
0.03982 TF:M07079 Factor: Cdx-2; motif: NNGYMATAAAA 1445 67
0.03982 TF:M03549_1 Factor: GATA-4; motif: AGATAAN; match class: 1 739 40
0.03982 TF:M01124 Factor: Oct-4; motif: ATTGWSWTGCWAAWN 4669 177
0.03982 TF:M10797 Factor: HOXA10; motif: RGTCGTAAAAN 4269 164
0.03982 TF:M04556 Factor: SRY; motif: AACAATNNNCATTGTT 6044 221
0.03982 TF:M01723_1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 385 25
0.03982 TF:M03559_1 Factor: Pit-1; motif: NNWWATTCAT; match class: 1 1042 52
0.03982 TF:M00102 Factor: CDP; motif: NWNATCGATTANYNN 3127 126
0.04025 TF:M01292_1 Factor: HOXA13; motif: ATAAMA; match class: 1 6372 231
0.04338 TF:M01149 Factor: DMRT4; motif: AATGTADCAAWTT 1398 65
0.04375 TF:M07364_1 Factor: NF-1; motif: TTGGCNN; match class: 1 552 32
0.04375 TF:M11894 Factor: Oct-2; motif: NNNATTATGCAW 2844 116

Particular Enrichments

Now we isolate the genes that are up or down regulated in just one subgroup.

G3 Enrichments

Up Enrichments

p_value term_id term_name term_size intersection_size
0.00237 CORUM:1439 PTGS2 homodimer complex 1 1
0.04900 HP:0010243 Abnormality of the epiphyses of the distal phalanx of finger 1 1
0.04900 HP:0010237 Epiphyseal stippling of finger phalanges 1 1
0.04900 HP:0010038 Short 2nd metacarpal 2 1
0.04900 HP:0009850 Triangular shaped middle phalanges of the hand 2 1
0.04900 HP:0009695 Stippling of thumb epiphysis 1 1
0.04900 HP:0009684 Stippling of the epiphysis of the distal phalanx of the thumb 1 1
0.04900 HP:0009662 Abnormality of the epiphysis of the distal phalanx of the thumb 1 1
0.04900 HP:0009638 Short proximal phalanx of thumb 2 1
0.04900 HP:0009606 Complete duplication of distal phalanx of the thumb 2 1
0.04900 HP:0009599 Abnormality of thumb epiphysis 2 1
0.04900 HP:0009575 Triangular shaped middle phalanx of the 2nd finger 2 1
0.04900 HP:0009566 Short distal phalanx of the 2nd finger 2 1
0.04900 HP:0009557 Aplasia/Hypoplasia of the distal phalanx of the 2nd finger 2 1
0.04900 HP:0009546 Triangular shaped phalanges of the 2nd finger 2 1
0.04900 HP:0009495 Pseudoepiphyses of the 2nd finger 1 1
0.04900 HP:0009378 Triangular shaped phalanges of the 5th finger 2 1
0.04900 HP:0009373 Type C brachydactyly 1 1
0.04900 HP:0009372 Type A2 brachydactyly 2 1
0.04900 HP:0009182 Triangular shaped middle phalanx of the 5th finger 2 1
0.04900 HP:0008096 Medially deviated second toe 2 1
0.04900 HP:0006263 Abnormality of the epiphyses of the 2nd finger 1 1
0.04900 HP:0005028 Widened proximal tibial metaphyses 2 1
0.04900 HP:0010255 Stippling of the epiphyses of the distal phalanges of the hand 1 1
0.04900 HP:0100387 Aplasia of the middle phalanges of the toes 1 1
0.04370 TF:M01185 Factor: BCL-6; motif: WRCTTTCKAGGRAT 4666 15

Down Enrichments

We have not identified any down regulated gene expressed just in G3 subgroup.

G4 Enrichments

Up Enrichments

We have not identified any up regulated gene expressed just in G4 subgroup.

Down Enrichments

p_value term_id term_name term_size intersection_size
0.00150 CORUM:6079 BAG6-HSPA2 complex 2 1
0.00150 CORUM:6736 PRAME-Cullin2 ubiquitin ligase complex 2 1
0.00150 CORUM:6738 PRAME-ElonginBC ubiquitin ligase 2 1
0.00168 CORUM:6078 HSPA2-ACR-PDIA6 complex 3 1
0.00225 CORUM:7556 PRAME complex 5 1
0.04135 WP:WP3888 VEGFA-VEGFR2 Signaling Pathway 389 2
0.04994 WP:WP4932 7q11.23 copy number variation syndrome 81 1
0.04994 WP:WP2359 Parkin-Ubiquitin Proteasomal System pathway 61 1

SHH Enrichments

Up Enrichments

p_value term_id term_name term_size intersection_size
0.01667 CORUM:7289 ANGPTL4-LRP6-SDC2 complex 3 1
0.01667 CORUM:7288 ANGPTL4-LRP6-SDC1 complex 3 1
0.01667 CORUM:6718 CALM1-KCNQ4(splice variant 1) complex 1 1
0.01667 CORUM:6440 CHRNA2-CHRNB4 complex 2 1
0.01667 CORUM:5748 2AR-mGluR2 complex 2 1
0.01667 CORUM:5747 2AR-mGluR2 complex 2 1
0.01667 CORUM:7290 ANGPTL4-LRP6-SDC4 complex 3 1
0.01667 CORUM:595 Kv4.2-DPP10 channel complex 2 1
0.01972 CORUM:2754 JUND-FOSB-SMAD3-SMAD4 complex 4 1
0.05000 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway 4 2
0.05000 GO:0060084 synaptic transmission involved in micturition 3 2
0.05000 GO:0060073 micturition 4 2
0.03788 REAC:R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors 13 2
0.03788 REAC:R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 6 2
0.03788 REAC:R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11 2
0.03788 REAC:R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors 9 2
0.03788 REAC:R-HSA-181431 Acetylcholine binding and downstream events 13 2
0.03788 REAC:R-HSA-622323 Presynaptic nicotinic acetylcholine receptors 11 2
0.00716 WP:WP1603 Nicotine Activity on Chromaffin Cells 4 2

Down Enrichments

p_value term_id term_name term_size intersection_size
0.03295 GO:0004143 diacylglycerol kinase activity 11 1
0.01297 HPA:0260142 hypothalamus; neuronal projections[=Medium] 25 1
0.01297 HPA:0260131 hypothalamus; neuronal cells[=Low] 24 1
0.01297 HPA:0260141 hypothalamus; neuronal projections[=Low] 26 1
0.01310 HPA:0260000 hypothalamus 35 1
0.02026 KEGG:00561 Glycerolipid metabolism 51 1
0.02026 KEGG:00564 Glycerophospholipid metabolism 82 1
0.02026 KEGG:04070 Phosphatidylinositol signaling system 93 1
0.02026 KEGG:05231 Choline metabolism in cancer 86 1
0.02367 KEGG:04072 Phospholipase D signaling pathway 136 1
0.02187 MIRNA:hsa-miR-95-5p hsa-miR-95-5p 110 1
0.02187 MIRNA:hsa-miR-7-2-3p hsa-miR-7-2-3p 139 1
0.02187 MIRNA:hsa-miR-7-1-3p hsa-miR-7-1-3p 150 1
0.02187 MIRNA:hsa-miR-495-3p hsa-miR-495-3p 154 1
0.02187 MIRNA:hsa-miR-551b-5p hsa-miR-551b-5p 131 1
0.02187 MIRNA:hsa-miR-3121-3p hsa-miR-3121-3p 119 1
0.02187 MIRNA:hsa-miR-5688 hsa-miR-5688 141 1
0.02695 REAC:R-HSA-114508 Effects of PIP2 hydrolysis 27 1

WNT Enrichments

Up Enrichments

p_value term_id term_name term_size intersection_size
0.01517 GO:1900449 regulation of glutamate receptor signaling pathway 4 1
0.01517 GO:1900451 positive regulation of glutamate receptor signaling pathway 1 1
0.01517 GO:1904020 regulation of G protein-coupled receptor internalization 3 1
0.01517 GO:1904021 negative regulation of G protein-coupled receptor internalization 2 1
0.01517 GO:0035588 G protein-coupled purinergic receptor signaling pathway 4 1
0.01517 GO:0060168 positive regulation of adenosine receptor signaling pathway 1 1
0.01517 GO:0001973 G protein-coupled adenosine receptor signaling pathway 4 1
0.01517 GO:0060167 regulation of adenosine receptor signaling pathway 2 1
0.03209 GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 16 1
0.03209 GO:0042984 regulation of amyloid precursor protein biosynthetic process 18 1
0.03209 GO:0042983 amyloid precursor protein biosynthetic process 18 1
0.03209 GO:0030322 stabilization of membrane potential 16 1
0.03209 GO:0023058 adaptation of signaling pathway 14 1
0.03209 GO:0022401 negative adaptation of signaling pathway 14 1
0.03209 GO:0002091 negative regulation of receptor internalization 14 1
0.03209 GO:0002031 G protein-coupled receptor internalization 10 1
0.03209 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 14 1
0.04207 GO:0035590 purinergic nucleotide receptor signaling pathway 25 1
0.04623 GO:0048261 negative regulation of receptor-mediated endocytosis 29 1
0.00786 GO:0031685 adenosine receptor binding 2 1
0.00786 GO:0031687 A2A adenosine receptor binding 1 1
0.00786 GO:0031802 type 5 metabotropic glutamate receptor binding 3 1
0.01572 GO:0035256 G protein-coupled glutamate receptor binding 8 1
0.01964 GO:0035254 glutamate receptor binding 20 1
0.01964 GO:0022842 narrow pore channel activity 18 1
0.01964 GO:0022841 potassium ion leak channel activity 15 1
0.01964 GO:0022840 leak channel activity 18 1
0.01435 HP:0001848 Calcaneovalgus deformity 10 1
0.01435 HP:0008138 Equinus calcaneus 5 1
0.01435 HP:0008119 Deformed tarsal bones 10 1
0.02795 HP:0008364 Abnormality of the calcaneus 26 1
0.03793 HP:0001838 Rocker bottom foot 52 1
0.03793 HP:0008365 Abnormality of the talus 53 1
0.00300 REAC:R-HSA-1299361 TWIK-related alkaline pH activated K+ channel (TALK) 2 1
0.00824 REAC:R-HSA-1296346 Tandem pore domain potassium channels 11 1
0.00848 REAC:R-HSA-5576886 Phase 4 - resting membrane potential 17 1
0.03599 REAC:R-HSA-5576891 Cardiac conduction 121 1
0.03599 REAC:R-HSA-1296071 Potassium Channels 99 1
0.04542 REAC:R-HSA-397014 Muscle contraction 184 1

Down Enrichments

p_value term_id term_name term_size intersection_size
0.00874 CORUM:668 BKCA-beta2AR-AKAP79 signaling complex 3 1
0.00874 CORUM:672 BKCA-beta2AR complex 2 1
0.00874 CORUM:2272 PICK1-GRIP1-GLUR2 complex 3 1
0.00874 CORUM:2699 ESR1-JUN-GRIP1 complex 3 1
0.00874 CORUM:6069 ESR1-GRIP1 complex 2 1
0.00874 CORUM:6726 GRASP1-GRIP1 complex 2 1
0.00874 CORUM:6748 KCNMA1-LRRC26 complex 1 1
0.00874 CORUM:7421 TSPY1-TSPYL5-USP7 complex 2 1
0.02060 CORUM:2919 Respiratory chain complex I (gamma subunit) mitochondrial 8 1
0.02126 GO:0035259 glucocorticoid receptor binding 8 2
0.02353 REAC:R-HSA-2022923 Dermatan sulfate biosynthesis 11 2

Transition Groups Enrichments

Up Enrichments

p_value term_id term_name term_size intersection_size
0.00749 GO:0005003 ephrin receptor activity 15 1
0.00749 GO:0005005 transmembrane-ephrin receptor activity 15 1
0.01923 GO:0019199 transmembrane receptor protein kinase activity 77 1
0.01923 GO:0004714 transmembrane receptor protein tyrosine kinase activity 59 1
0.02177 GO:0004713 protein tyrosine kinase activity 109 1
0.02210 KEGG:04360 Axon guidance 177 1
0.01449 MIRNA:hsa-miR-4290 hsa-miR-4290 76 1
0.01449 MIRNA:hsa-miR-3675-3p hsa-miR-3675-3p 125 1
0.01449 MIRNA:hsa-miR-216b-5p hsa-miR-216b-5p 113 1
0.01449 MIRNA:hsa-miR-6779-3p hsa-miR-6779-3p 54 1
0.01449 MIRNA:hsa-miR-4762-5p hsa-miR-4762-5p 112 1
0.01449 MIRNA:hsa-miR-519d-5p hsa-miR-519d-5p 123 1
0.01449 MIRNA:hsa-miR-520f-5p hsa-miR-520f-5p 60 1
0.01656 MIRNA:hsa-miR-4667-3p hsa-miR-4667-3p 204 1
0.01656 MIRNA:hsa-miR-4691-5p hsa-miR-4691-5p 197 1
0.01656 MIRNA:hsa-miR-6792-3p hsa-miR-6792-3p 198 1
0.01756 MIRNA:hsa-miR-5193 hsa-miR-5193 238 1
0.01948 MIRNA:hsa-miR-18a-3p hsa-miR-18a-3p 288 1
0.01049 REAC:R-HSA-3928665 EPH-ephrin mediated repulsion of cells 48 1
0.01049 REAC:R-HSA-3928663 EPHA-mediated growth cone collapse 27 1
0.01267 REAC:R-HSA-2682334 EPH-Ephrin signaling 87 1
0.03968 REAC:R-HSA-422475 Axon guidance 431 1
0.03968 REAC:R-HSA-9675108 Nervous system development 454 1

Down Enrichments

We have not identified any down regulated gene expressed just in Transition subgroup.